Senior Research Associate, Rodent Neuroscience

Astera Institute • Emeryville, CA

1d • Onsite

About The Position

The Senior Research Associate will play a central role in building and running our rodent program. You will care for the colony, prepare animals for high-resolution functional imaging, perform the surgeries that make those experiments possible, and process tissue afterward. You will work directly with the scientists whose experiments depend on your work. The ideal candidate is meticulous, independent, and approaches surgical work with the precision and care it demands. You can run a cranial window implantation and achieve consistent, quality results. You keep records that other people can actually use. Understanding how the brain works at the level of neural circuits requires carefully designed experiments in animal models. The mouse remains the most powerful system for this work because of its genetic tools, well-characterized neurobiology, and shared circuit architecture with other mammals. We take the responsibility seriously. All of our rodent work is conducted under a veterinarian-supervised program with full IACUC oversight. We are committed to the principles of Replacement, Reduction, and Refinement, and we design studies to use the fewest animals necessary, refine procedures to minimize distress, and share data widely to avoid unnecessary duplication across labs. Animal welfare is inseparable from scientific rigor, and we build our program accordingly.

Requirements

• Three or more years of hands-on experience with laboratory mice in a research setting.
• Demonstrated proficiency with rodent surgery, including stereotaxic procedures, aseptic survival surgery, and chronic preparations.
• Steady hands and excellent fine-motor control.
• Disciplined record keeping and strong organizational habits.
• Strong working knowledge of IACUC protocols and willingness to contribute to protocol drafting and amendments.
• Experience handling DEA-scheduled anesthetics and analgesics under proper oversight.
• Independence and proactive judgment.
• A sincere commitment to animal welfare, and the judgment to carry out every aspect of the work, including end-of-study procedures, with care and composure.

Nice To Haves

• Prior experience with cranial windows for two-photon imaging, AAV injections, GRIN lens or miniscope implants, or behavioral training for head-fixed paradigms.

Responsibilities

• Oversee a mouse colony, including breeding, weaning, genotyping coordination, and daily welfare monitoring.
• Train mice on perceptual and cognitive behavioral tasks.
• Perform stereotaxic surgeries under aseptic technique, including animal preparation, anesthesia, intracortical injection of viral vectors and reagents, cranial window implantation, and post-operative care and analgesia.
• Maintain chronic preparations and monitor animal health across long experiments, adjusting approaches when conditions drift.
• Perform terminal procedures under deep anesthesia, including transcardial perfusion, followed by tissue extraction, sectioning, staining, and basic histology.
• Keep detailed records of every animal, surgery, and reagent.
• Help shape rodent lab protocols and workflow as the program grows.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior