Senior Research Associate, Oligonucleotide Chemistry

CAMP4 Therapeutics•Cambridge, MA

3d•$85,000 - $110,000•Onsite

About The Position

CAMP4 is seeking a passionate and innovative researcher to join our Chemistry team. The candidate will contribute to CAMP4’s in-house high throughput oligonucleotide synthesis and formulation capabilities. This is a laboratory-based role, and the successful candidate will bring experience of oligonucleotide synthesis, purification and analysis to advance our antisense oligonucleotide (ASO) pipeline. The successful candidate will be creative and flexible with enthusiasm for contributing in a high efficiency and fast-paced environment that is focused on urgently advancing drug candidates to help the unmet medical need of patients with CNS disorders. This position will be based in our Cambridge, MA location.

Requirements

Strong interpersonal, teamwork, communication, and organizational skills
Ability to thrive in a dynamic, fast-paced, innovative environment
Strong ability to manage timelines
Maintain a high level of scientific integrity and lab safety
Effectively engage with team, both willing to voice opinions and share ideas, while being receptive to feedback and other points of view.
BS in chemistry or relevant life sciences with 5+ years or MS plus 2+ years of industry experience in oligonucleotide synthesis
Demonstrated proficiency operating automated oligonucleotide synthesis equipment (Mermade, Dr. Oligo, etc.) is strongly desirable
Competency with analytical techniques such as HPLC, LC-MS and UV-Vis

Nice To Haves

Knowledge of oligonucleotide purification including ion-exchange and reverse-phase chromatography and experience with laboratory automation such as liquid handlers is a plus

Responsibilities

Independently execute high throughput oligonucleotide synthesis and characterization to meet project timelines.
Perform oligonucleotide formulation and characterization, including assessment of concentration, purity, stability, and other critical quality attributes.
Develop, conduct, and interpret analytical methods (e.g., HPLC, LC-MS, UV-Vis) to characterize and quantify oligonucleotides.
Operate, troubleshoot and maintain laboratory instruments including automated oligonucleotide synthesizers, LC-MS, and HPLC.
Collaborate with stakeholders across cross-functional teams to align on projects and meet timelines.
Manage inventory of oligonucleotide sequences, reagents and critical supplies.
Maintain thorough and timely records of experiments in accordance with company policies and procedures.