Associate Director/Director, Antisense Oligonucleotide Chemistry

CAMP4 Therapeutics•Cambridge, MA

4d•$175,000 - $230,000•Onsite

About The Position

We are seeking an experienced and highly motivated Associate Director of Antisense Oligonucleotide (ASO) Chemistry to lead a small team of scientists focused on discovery-stage oligonucleotide synthesis and formulation. This individual will lead a small team of chemists, provide both scientific and strategic guidance, and help shape the evolution of our ASO platform capabilities. The ideal candidate is a collaborative, adaptable oligonucleotide chemistry leader with deep technical expertise. This is an onsite position.

Requirements

Ph.D. in Chemistry, Chemical Biology, or a related field with 8+ years of relevant experience.
Proven expertise in antisense oligonucleotide chemistry or related nucleic acid modalities.
Demonstrated experience leading and developing scientific teams.
Strong understanding of ASO synthesis technologies, purification approaches, and formulation principles.
Excellent communication, writing, and organizational skills.
Demonstrated success working in fast‑paced, matrixed environments with shifting priorities.
Ability and willingness to perform hands‑on laboratory work.
Strong problem-solving skills, scientific creativity, and a collaborative mindset.

Nice To Haves

Highly adaptable and energized by rapidly evolving science.
Comfortable balancing tactical execution with strategic thinking.
Strong interpersonal skills and a track record of effective cross‑functional partnership.
Motivated by mentoring others and building strong team culture.

Responsibilities

Lead, mentor, and develop a team of ~3 scientists engaged in ASO synthesis, purification, and formulation.
Set clear priorities, manage workflows, and ensure high‑quality, timely scientific execution.
Foster a collaborative, inclusive, and growth‑oriented team culture.
Oversee oligonucleotide synthesis, including small and medium scale synthesis, and external vendor management.
Drive method development and process optimization for high-throughput synthesis, purification, and formulation.
Maintain strong technical rigor across all experimental work; provide troubleshooting, guidance, and hands‑on laboratory support as needed.
Evaluate new technologies, methodologies, and platforms to enhance ASO chemistry capabilities.
Partner closely with discovery and platform teams to drive discovery projects and innovation.
Communicate complex chemistry concepts clearly to diverse audiences, ensuring alignment between chemistry strategy and program goals.
Contribute to project planning, timelines, risk assessments, and decision‑making.
Provide scientific and strategic insights into ASO program direction, platform development, and long‑term capability planning.
Help define and drive improvements in ASO design workflows, synthesis efficiency, and quality standards.
Ensure accurate documentation, data organization, and reporting across projects and team activities.
Contribute to internal presentations, external collaborations, and regulatory‑relevant documentation as needed.