Associate Director, Medicinal Chemistry

Revolution Medicines•Redwood City, CA

5d•$186,000 - $233,000•Hybrid

About The Position

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: Revolution Medicines is seeking a scientifically talented individual to join our world-class Discovery Research organization as an Associate Director of Medicinal Chemistry. This position focuses on early hit discovery and offers opportunities to play a critical role across multiple stages of drug discovery, including hit-to-lead, lead optimization, and delivering high-quality anti-cancer drug candidates. This is a managerial role reporting to the Director of Medicinal Chemistry and includes both scientific leadership and people management responsibilities within a highly collaborative, cross-functional environment.

Requirements

Ph.D. degree in chemistry.
Minimum of 5 years of experience in the pharmaceutical/biotech industry with a track record of scientific innovation in the medicinal chemistry discipline.
Working knowledge of modern medicinal chemistry and drug discovery approaches.
Track record of involvement in identifying a development candidate with a deep understanding of hit generation, hit-to-lead, structure-based drug design and lead optimization.
Experience managing scientific collaborations and external CRO resources.
Strong problem-solving skills with sound technically driven decision-making
Effective written and verbal communication skills and interpersonal
An innovative team-player and leader with capacity to be effective in a dynamic and fast-paced environment.

Nice To Haves

Experience in beyond Rule-of-Five (bRo5) small-molecule drug discovery.
Experience in oncology drug discovery research.
Experience in targeting historically undruggable targets through approaches such as covalent inhibitors, macrocycles, molecular glues, and other alternative modalities.
Demonstrated leadership experience, including mentoring and developing scientists within multidisciplinary teams.

Responsibilities

Lead and execute medicinal chemistry strategies for early-stage discovery programs, including target validation, hit finding, and hit-to-lead optimization.
Design and drive efficient, hypothesis-driven Design–Make–Test–Analyze (DMTA) cycles to deliver differentiated small-molecule leads and development candidates.
Identify key scientific risks, define mitigation strategies, and provide data-driven recommendations at project decision points.
Collaborate closely with cross-functional partners in Screening Sciences, Discovery Biology, Computational Chemistry, DMPK, Pharmacology, and CMC to ensure integrated project progression and timely delivery.
Communicate project strategy, data, and conclusions clearly to cross-functional teams and senior leadership.
Provide scientific oversight and direction for external chemistry CRO activities to ensure quality, efficiency, and alignment with program objectives.
Contribute to invention disclosures, patent filings, and external scientific publications.
Champion best practices in medicinal chemistry and continuously improve scientific and operational effectiveness.
Manage, coach, and mentor medicinal chemists, providing technical guidance, performance feedback, and career development support.
Foster a culture of scientific excellence, accountability, and collaboration consistent with RevMed’s Integrated Discovery Research vision.