Senior Associate Scientist, In vivo Pharmacology, Neuroinflammation/Neurodegeneration

Pfizer • Cambridge, MA

2d • Onsite

About The Position

The Pfizer Inflammation & Immunology Research Unit (I&I RU) in Cambridge is seeking a Senior Associate Scientist to support in vivo studies in neuroinflammatory and neurodegenerative disease models. A key focus of this role is immunohistology, including tissue processing, immunolabeling, imaging, and quantitative analysis to characterize cellular and molecular responses. The scientist will perform rodent in vivo pharmacology (dosing, surgeries, behavioral assessments) and contribute to integrated mechanistic studies across in vivo, in vitro, and ex vivo platforms. Ex vivo responsibilities also include transcriptional, proteomics, and flow cytometric readouts that complement immunohistological findings. This position offers an opportunity to drive impactful research in neuroinflammation while collaborating closely with multidisciplinary project teams to advance therapeutic discovery. What You Will Achieve In this role, you will: Design, execute, and analyze data from various experiments, including in vitro cell-based assays and functional tissue bath assays. Plan and conduct in vivo studies to support the therapeutic portfolio, including drug formulation and administration through various routes A key focus of this role is immunohistology, including tissue processing, immunolabeling, imaging, and quantitative analysis. Follow procedures for assignments with general instructions and work under moderate supervision with regular review. Identify activities to support team goals and actively participate and contribute as a team member.

Requirements

• A Bachelor's Degree with at least 3 years of relevant experience or a Master's Degree with relevant experience.
• Exceptional written, oral communication, and presentation abilities.
• Proficiency in analysis tools like Excel, GraphPad and PowerPoint for documenting experiments and analyzing/presenting data
• Strong organizational skills and attention to detail.
• Hands on experience with standard immunohistological methods.
• Experience in conducting and managing in vivo studies.
• Knowledge of principles, concepts, and practices of pharmacology.

Nice To Haves

• Proficiency in script-based data analysis and managing large datasets on advanced platforms beyond Microsoft Excel.
• Experience with in vivo preclinical research in neurodegeneration/neuroinflammation, basic understanding of immunology/autoimmunity.
• Excellent time-management skills, demonstrating the ability to adhere to pre-established experimental designs.
• Capability to develop innovative protocols and methods independently.
• Strong problem-solving skills and the ability to choose between alternatives to solve moderately complex problems
• Experience using common AI tools, including generative technologies such as ChatGPT or Microsoft Copilot.

Responsibilities

• Design, execute, and analyze data from various experiments, including in vitro cell-based assays and functional tissue bath assays.
• Plan and conduct in vivo studies to support the therapeutic portfolio, including drug formulation and administration through various routes
• Immunohistology, including tissue processing, immunolabeling, imaging, and quantitative analysis.
• Perform rodent in vivo pharmacology (dosing, surgeries, behavioral assessments)
• Contribute to integrated mechanistic studies across in vivo, in vitro, and ex vivo platforms.
• Ex vivo responsibilities also include transcriptional, proteomics, and flow cytometric readouts that complement immunohistological findings.

Benefits

• participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary
• 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
• paid vacation, holiday and personal days
• paid caregiver/parental and medical leave
• health benefits to include medical, prescription drug, dental and vision coverage

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 5,001-10,000 employees