Associate Director, In Vivo Pharmacology & Translational Science

Flagship Pioneering, Inc.•Cambridge, MA

3d•$157,000 - $198,000

About The Position

Flagship Labs 111 Inc. (FL111) is a privately held, early-stage biotechnology company pioneering a novel platform harnessing innovations in chemistry and machine learning to address challenging biology. FL111 is backed by Flagship Pioneering, bringing the courage, vision, and resources to guide FL111 from platform validation to patient impact. We are seeking collaborative, creative and relentless problem solvers that share our passion for impact to join us! We are seeking an Associate Director, In Vivo Pharmacology & Translational Science to lead all in vivo activities from early discovery through preclinical development. This role will own the design, execution, and interpretation of in vivo PK, PD, and efficacy studies, with a strong focus on oncology and small-molecule modalities. The ideal candidate is an accomplished in vivo pharmacologist who can manage CROs and external technicians, while also rolling up their sleeves to troubleshoot and ensure studies are delivered on time. This individual will build and scale our in vivo capabilities, establish best practices, and serve as the in vivo leader at FL111.

Requirements

Ph.D./M.D. with 5-10+ years of industry experience in preclinical development of small molecule modalities.
Deep expertise in Oncology and Cancer Biology, specifically in designing and executing studies using diverse in vivo oncology models (e.g., CDX, PDX, humanized, syngeneic).
Expertise in the preclinical characterization of heterobifunctional small molecules (e.g., PROTACs)
Proven ability to lead projects, integrating PK, PD, and efficacy data to drive compound optimization and Go/No Go decisions.
Extensive experience managing external in vivo work at CROs, including experimental design, study monitoring, and data quality oversight.

Responsibilities

Project leadership: serve as the in vivo lead on project teams, accountable for end-to-end planning, execution, and delivery of all in vivo PK, PD, and efficacy studies.
Study design and execution: develop and execute in vivo studies to evaluate compound exposure (PK), target engagement and biomarkers (PD), and anti-tumor activity (efficacy) across various oncology models and small molecule modalities; hands-on execution.
CRO management and operations: lead the day-to-day management of external in vivo work at CROs, including protocol review, study monitoring, data quality oversight, and vendor qualification/onboarding.
Collaborate closely with Chemistry, DMPK, and Biology teams to refine compound design and formulation based on integrated PK/PD/efficacy data.
Documentation & Communication: Establish fit-for-purpose in vivo workflows and SOPs, document experiments & results, and communicate scientific results effectively through clear presentations.