Pioneering Medicines: Scientist / Senior Scientist, Invitro Pharmacology Contractor

Flagship Pioneering, Inc.•Cambridge, MA

5d•$108,000 - $175,500•Onsite

About The Position

We are seeking an on-site, lab-based in-vitro scientist in drug discovery who enjoys collaborating with cross-functional teams. Under appropriate guidance, the role involves designing research studies, performing experiments, and analyzing data. The ideal candidate will preferably have expertise in cardiovascular physiology including but not limited to cardio-metabolic or cardiac physiology, along with experience in in-vitro biochemical assays, cell culture, organoid models, hiPSC cultures, cell biology assays, and ex vivo techniques. As and when required, this person will work closely with other stakeholders to help achieve the research goals.

Requirements

Ph.D. in biochemistry, biotechnology, biophysics, biology, or a related field.
3+ years of post-doctoral experience is preferred
Over three years of experience in academia and/or industry, ideally in the cardiometabolic therapeutic field, is a plus.
Broad experience in protein and peptide chemistry is preferable
Have working Skilled in culturing and handling human primary cells, including primary cardiomyocytes and hiPSC-derived cardiomyocytes, is preferable
Expertise working on molecular biology methods, DNA, RNA isolation, siRNA, and transduction in primary cells.
Proficiency in common laboratory techniques such as qPCR, flow cytometry, ELISA, Western blotting, plate reader assays, and microscopy.
Working knowledge of invitro pharmacology, in cell-based systems.
Attention to detail and ability to analyze and summarize scientific data, clearly communicate updates and reports to the team and stakeholders, and perform detailed documentation of experimental results via ELN (Electronic Lab Notebook))
Excellent verbal communication, presentation, and interpersonal skills are required.
Proficient in scientific software (e.g., GraphPad Prism, FlowJo, etc.)
Publication record in cardiovascular, cardiometabolic, or related research.

Nice To Haves

Industrial experience or experience working with academic/industrial collaborators and/or CROs preferred
Research background in cardiology or metabolism.
Hands-on experience with gene-based approaches such as CRISPR and RNA interference is a plus
Understanding of the general drug discovery & development process, from target identification and validation is a bonus.

Responsibilities

Support in vitro screening, characterization, and mechanism of action studies by utilizing various biochemical, biophysical, and cellular techniques to explore signaling pathways for target identification and validation, employing modalities like small molecules, peptides, and other biologics.
Develop cell-based assays utilizing primary cardiomyocytes, cardiac cell lines, iPSCs, and organoids, along with ex vivo experiments to aid in in vitro pharmacology and translational research.
Collaborate with key stakeholders of the in vitro, in vivo, and translational teams and other necessary stakeholders to support daily laboratory operations.
Participate and present data at internal and external meetings