Scientist, In vitro Assay and Method Development

Elanco•Indianapolis, IN

5d•Hybrid

About The Position

At Elanco (NYSE: ELAN) – it all starts with animals! As a global leader in animal health, we are dedicated to innovation and delivering products and services to prevent and treat disease in farm animals and pets. At Elanco, we are driven by our vision of Food and Companionship Enriching Life and our purpose – all to Go Beyond for Animals, Customers, Society and Our People. At Elanco, we pride ourselves on fostering a diverse and inclusive work environment. We believe that diversity is the driving force behind innovation, creativity, and overall business success. Here, you’ll be part of a company that values and champions new ways of thinking, work with dynamic individuals, and acquire new skills and experiences that will propel your career to new heights. Making animals’ lives better makes life better – join our team today! Your Role: Scientist, In vitro Assay and Method Development As the In vitro Assay Development Scientist, you will be responsible for method transfer and the training of junior scientists in the design, development, optimization, and execution of cell-based and biochemical assays. You will work in a collaborative, cross-functional environment focusing on the characterization of small molecule compounds and the elucidation of their mechanism of action. This role offers an exciting opportunity to provide critical data to guide medicinal chemistry efforts and contribute directly to the advancement of our innovation pipeline.

Requirements

B.S.
Minimum 20 years relevant academic or industry experience in method transfer and training of junior scientists
Tops skills include various assay detection technologies (e.g., absorbance, fluorescence, luminescence) and data analysis software.

Nice To Haves

Experience with protein expression, purification, and characterization is a plus.
An understanding of medicinal chemistry and drug discovery principles.
Excellent organizational skills and the ability to manage multiple tasks and projects simultaneously.
Strong collaborative spirit and clear communication skills.

Responsibilities

Lead method transfer and training of junior scientists in cell-based and biochemical assay development and optimization
Collaborate cross-functionally in the build-out of new Discovery Bioassay capabilities at our new Indianapolis HQ
Design, develop, and validate novel and robust cell-based and enzymatic assays suitable for high-throughput screening (HTS).
Characterize protein inhibitors by determining IC50 values, potency (Ki), and their mechanism of inhibition (e.g., competitive, non-competitive, reversible, irreversible).
Implement and execute screening funnels to evaluate compound libraries, generating high-quality, reproducible data to drive structure-activity relationship (SAR) analysis.
Collaborate internally and externally with protein production to ensure the availability of high-quality, active protein preparations for use in assays.
Proactively research and implement new assay technologies, detection methods (e.g., absorbance, fluorescence, luminescence), and instrumentation to increase assay quality and efficiency.
Analyze, interpret, and present complex experimental data to colleagues within project teams.
Troubleshoot assays to ensure high-quality, reproducible results.
Stay current with scientific literature and proactively evaluate new technologies, instrumentation, and methodologies to improve assay performance and throughput.
Maintain records of experimental designs, protocols, and results in electronic lab notebooks (ELN).