Senior Scientist, Assay Development

Johnson & Johnson•Cambridge, MA

13d•Onsite

About The Position

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com About Innovative Medicine: Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine We are searching for the best talent for a Senior Scientist, Assay Development to be onsite in Cambridge, MA. Purpose: The in Vivo Antibody Discovery group within Biologics Discovery is responsible for lead antibody generation from immunized animals with state-of-the-art technologies including single B cell sorting, hybridoma, display and microfluidics. As a member of the IVAD Group, this role will be responsible for the development and implementation of biochemical or cell-based binding and functional assays to support antibody generation against targets in different disease areas. In-depth knowledge and hands-on experience in assay development on Beacon microfluidics will be preferred. A strong understanding of cell biology and disease molecular pathways will also be important. This is a critical function in a multifaceted Biologics Discovery organization committed to bringing the next generation of biotherapeutic molecules to patients. We are looking for a motivated candidate with scientific and technical expertise who can collaborate across discovery areas to bring value to our portfolio of innovative drug concepts. Proficiency to work within a highly coordinated, fast-paced environment will be a significant attribute. An additional knowledge base in the areas of oncology, immunology, infectious disease, or cardiovascular disease would be a plus. If this sounds like you, come join our team!

Requirements

Minimum of a Bachelor’s degree is required
PhD in Molecular Biology, Biomedical Engineering, Biochemistry or a related field is highly preferred
Minimum 4 years of experience in the pharmaceutical industry and/or academic setting
Hands-on experience in assay development with expertise on protein-based binding assays and cell-based binding and functional assays
In-depth knowledge on mAb, bi-specifics and multi-specifics as therapeutics
Working knowledge on microfluidics-based antibody discovery platform (ideally Beacon)

Nice To Haves

Assay development experience on microfluidics-based antibody discovery platform
Flow cytometry expertise for single B cell sorting
Experience or knowledge on generation of right reagents/cell lines for assay development on Beacon platform
An additional knowledge base in the areas of oncology, immunology, infectious disease, or cardiovascular disease

Responsibilities

Design and optimize biochemical/cell-based binding and functional assays with appropriate reagents for antibody screening
Execute antibody discovery workflow on Beacon microfluidics platform to screen for functional antibody hits
Evaluate animal serology using appropriate assays to select animals for screening
Present research findings in internal meetings, clearly communicating scientific results and providing insights into data interpretation.
Collaborate with multidisciplinary teams across functional areas to advance therapeutic programs in a dynamic and fast-paced environment.
Document work accurately and promptly using Electronic Lab Notebook systems (e.g., Signal) and create detailed SOPs.

Benefits

medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.
Company’s consolidated retirement plan (pension) and savings plan (401(k)).
Vacation –120 hours per calendar year
Sick time - 40 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
Holiday pay, including Floating Holidays –13 days per calendar year
Work, Personal and Family Time - up to 40 hours per calendar year
Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
Condolence Leave – 30 days for an immediate family member: 5 days for an extended family member
Caregiver Leave – 10 days
Volunteer Leave – 4 days
Military Spouse Time-Off – 80 hours