Scientist I, Antibody Engineering

Astellas Pharma • Burlingame, CA

5d • Onsite

About The Position

Astellas is a global life sciences company committed to turning innovative science into VALUE for patients. They provide transformative therapies in disease areas that include oncology, ophthalmology, urology, immunology and women's health, pioneering new healthcare solutions for diseases with high unmet medical need. The company seeks passionate individuals who thrive in dynamic environments, embrace new ideas, take intelligent risks, act with unwavering integrity, and are deeply committed to making a tangible impact. Astellas is announcing a Scientist I, Antibody Engineering opportunity at the Xyphos affiliate at the Astellas West Coast Innovation and Research Center in South San Francisco, CA. The role is for a talented Scientist to join the Antibody Engineering team in South San Francisco, contributing to the design, molecular biology, purification and characterization of next-generation biologics, with a focus on innovative platform technology development for oncology programs.

Requirements

• PhD with 0-2 years, MS with 4+ years, or BS with 6+ years of related experience in protein sciences team
• Extensive experience in purification of mAbs, bi-/multi-specific antibodies, and Fc-fusion proteins using AKTA FPLC by protein A/G, IMAC, HIC, IEX, SEC chromatography methods
• Experience in protein characterization techniques, such as analytical SEC, HIC, cIEF, CE-SDS/SDS-PAGE, DSF, and endotoxin testing
• Demonstrated ability to conceive and design experiments, develop and optimize protocols/assays, and interpret experimental results
• Demonstrated ability to work independently with minimal supervision and ability to effectively collaborate with other teams; collegiality is a critical attribute
• Diligence and meticulous attention to detail in experimentation and ELN record keeping
• Strong work ethic, good team player, willingness to fill gaps, demonstrated flexibility/adaptability to meet critical research related timelines
• Collaborative mindset to work with global team members

Nice To Haves

• Proficiencies in molecular biology techniques, including DNA construct design, PCR, DNA purification and molecular cloning
• Prior experience in SPR/BLI and/or mass spectrometry
• Knowledge of conditional activation: e.g. masking technologies, tumor-specific activation or payload delivery

Responsibilities

• Lead antibody and protein production by performing purification of mAbs, bi-/multi-specific antibodies, and Fc fusion proteins at various scales using CHO and 293 cell lines
• Perform QC and characterize recombinant antibodies and proteins from both internal and external sources; summarize results and present to project teams
• Act as a technical lead for maintaining priority work and troubleshooting production issues
• Plan and coordinate internal and external production activities and communicate with key stakeholders regularly

Benefits

• Medical, Dental and Vision Insurance
• Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down
• 401(k) match and annual company contribution
• Company paid life insurance
• Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions
• Long Term Incentive Plan for eligible positions
• Company fleet vehicle for eligible positions
• Referral bonus program

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Number of Employees: 5,001-10,000 employees