Scientist, Cell Biology

Twist Bioscience • Quincy, MA

3d

About The Position

We are seeking a motivated individual to join our team and expand our antibody characterization department. Using state-of-the-art technologies and workflows, this Scientist, Cell Biology would work with the Antibody Characterization team to ensure project-specific deliverables are met across a diverse panel of discovery campaigns and contract services. The role would involve wet lab experimental design, execution, and data analysis for multiple custom antibody development projects incorporating various biologics assay formats.

Requirements

• Master’s degree with 3-5 years of related experience, or a PhD with 0-2 years’ experience. Industry experience strongly preferred.
• Strong understanding of antibody discovery and characterization, preferably focusing on assay development and protein characterization.
• Cell culture experience with adherent and suspension cancer cell lines, engineered cell lines, or primary cell lines is required.
• Direct experience with flow cytometry and/or cell-based functional assays is required.
• Ability to effectively design, troubleshoot and optimize processes to meet a wide range of project needs.
• Ability to work independently but also collaborate and effectively communicate within and across departmental teams.
• Exceptional written and verbal communication skills
• Highly organized, detail oriented and able to operate in a fast-paced and growing environment

Nice To Haves

• Previous experience with BLI and/or SPR is strongly preferred.
• Direct experience with ELISA is preferred.

Responsibilities

• Developing, running and troubleshooting high throughput cell-based functional assays and multicolor flow cytometry to characterize antibodies
• Performing cell culture on a variety of cell lines, including adherent and suspension cell lines to support cell-based assays.
• Performing titer testing, screening, and antibody validation by ELISA and high throughput multicolor flow cytometry
• Performing antibody characterization experiments using advanced label-free analytical techniques (e.g. BLI and SPR) in a variety of formats to evaluate binding kinetics, ligand blocking, and binning
• Sample handling, sample inventory tracking and assisting with automation integration into the department
• Concurrently execute multiple antibody discovery projects requiring wet lab activities, data analysis, report generation and preparation of deliverables
• Record and communicate experimental details, draft reports, and deliver data with a high level of integrity and ethics

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level