Scientist, Cell Biology & Screening

e184•Portland, OR

3d•Onsite

About The Position

e184 is a biotechnology research company advancing in vitro gametogenesis to transform reproductive medicine. We're developing integrated platforms that combine cellular reprogramming, machine learning-guided optimization, multi-omics analysis, and automated experimental workflows to enable gamete development for individuals facing reproductive challenges. We're assembling interdisciplinary teams across cell and molecular engineering, synthetic biology, epigenetic editing, bioinformatics and computational biology to tackle one of biology's most impactful problems - returning the fundamental right to procreate. We are seeking an independent, creative scientist to lead the design and execution of high-throughput screening campaigns aimed at identifying reprogramming factors that control cellular differentiation programs. Reporting to the Team Lead and Chief Scientific Officer, you will play a foundational role in establishing our screening platforms from the ground up, working collaboratively with computational biologists and cell biology experts within a small, mission-driven team. This position offers exceptional autonomy and ownership in a flat organizational structure, with direct impact on critical proof-of-concept milestones and the opportunity to tackle challenging biological problems using novel approaches at the forefront of stem cell and developmental biology.

Requirements

PhD in Cell Biology, Molecular Biology, Genetics, Biochemistry, or related field
Hands-on experience with mammalian cell culture, including iPSCs
Demonstrated experience with high-throughput screening approaches (pooled and/or arrayed formats)
Proficiency with genome editing technologies (CRISPR/Cas9 or similar)
Experience developing and optimizing quantitative cellular assays
Molecular biology techniques (cloning, plasmid design, library construction)
Flow cytometry or high-content imaging for cellular analysis
Experimental design and data analysis for screening campaigns
Ability to work both independently and as part of a team
Comfortable with ambiguity in an early-stage environment

Nice To Haves

Postdoctoral training or 1-3 years of industry experience
Track record of high-throughput screening from design through validation
Experience with reporter cell line development and validation
Familiarity with arrayed screening platforms and automation
Experience with sequencing technologies (RNA-seq, single-cell RNA-seq, or genomic screening readouts)
Proficiency with bioinformatics tools and programming languages (R, Python)
Knowledge of functional genomics approaches
Publications demonstrating expertise in relevant areas
Experience in biotech startup or fast-paced research environment
Familiarity with designing iterative experimental strategies
Prior involvement in target discovery or validation programs

Responsibilities

Contribute to breakthrough technologies in cellular biology with potential to transform human health.
Work on challenging scientific problems at the forefront of stem cell biology and functional genomics.
Take scientific ownership of critical projects from conception through execution.
Gain experience spanning screening, genome editing, assay development, and computational analysis - building a diverse skill set valuable across the biotech industry.
Work alongside domain-expert scientists and computational biologists in a highly collaborative, mission-driven culture where your contributions directly shape company direction.
This role offers exposure to the full lifecycle of target discovery-from high-throughput screening through mechanistic validation-as well as opportunities to develop leadership skills, and contribute to scientific publications and patent applications.
Hands-on involvement in building experimental platforms and workflows from the ground up rather than inheriting established systems; direct collaboration with founders and leadership team; opportunity to wear multiple hats and develop skills across experimental and computational domains; work in a well-funded startup.