Sr Scientist, Cell Biology
About The Position
Programmable DNA, the software of Life, is finally here! Twist Bioscience is developing a disruptive, synthetic DNA technology that will change the world, enabling widespread health and sustainability. Synthetic biologists will use our products to engineer how organisms produce cures to diseases, make everyday chemicals by using the atmosphere as the carbon source, enable plants to make their own fertilizers, and to create in-vivo diagnostics that alert us when we are sick, and many more applications. We are seeking a motivated, enthusiastic, and outstanding Senior Scientist, Cell Biology, to join our antibody discovery efforts. This associate will play multiple roles within the Pharma group and will work within a team responsible for antibody discovery and characterization utilizing mammalian cell culture, HT FACS, and develop/execute HT functional cell based assays.
Requirements
- Minimum of 2 years industry related work experience or relevant postdoc; with an educational background that includes a Ph.D. in cell biology, biochemistry, immunology, protein biochemistry, or related discipline
- Have an understanding of antibody structure and function
- Strong background in cell culture and flow cytometry/FACS is required
- You are excited to learn new techniques and work collaboratively with others
- You thrive in a dynamic, quickly changing environment where we were work individually and on teams
Nice To Haves
- Experience with ELISA-based detection of cytokines and other soluble factors from cell supernatant
- Experience with molecular cloning to generate constructs to express proteins.
- Ability to multitask and thrive in a fast-paced and challenging environment
- Strong organization skills and proficiency in computer skills including various databases
- Excellent oral/written communication and interpersonal skills a must
- Experience in screening anti-GPCR antibodies in functional assays preferred
- Experience expressing antibodies in HEK293/CHO and purifying them using traditional methods preferred
- Excellent problem-solving capabilities
- Extraordinary attention to detail and planning
- Proficiency with Microsoft Word, Excel, and PowerPoint
Responsibilities
- Characterizing antibodies, VHHs or other binder formats in cell-based functional assays, including high-throughput formats of cytokine release assays, cell-based reporter assays, ligand binding studies, cAMP release, immunogenicity assays and MSD assays.
- Perform high-throughput flow cytometry and FACS cell binding assays with antibodies against transiently transfected cell lines and stably expressed cell lines.
- Establish target over-expressing cell lines for antibody discovery work
- Understand and assess immuno-oncology signal transduction pathways via in vitro cell-based assays.
- Plan, perform, analyze, and document laboratory experiments in support of antibody discovery
- Present your findings to both internal and external stakeholders
- Evaluate and support the implementation of new technologies
- Maintain laboratory instruments and logistics
- Work collaboratively under aggressive timelines in a contract research setting
Benefits
- In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
