Research & Development Scientist III

Baylor Genetics•Houston, TX

13h

About The Position

SUMMARY: We are seeking a highly motivated and experienced R&D Scientist to join our dynamic, fast-paced team focused on driving innovation in the genomic diagnostics field. The R&D Scientist will play a critical role in developing new sequencing based diagnostic assays. This role is ideal for a scientist with a Ph.D. in molecular biology, biochemistry, genetics, or a related field, and a strong background in assay development and validation. The successful candidate will play a key role in developing and optimizing tissue biopsy and liquid biopsy workflows, contributing to the advancement of cutting-edge molecular diagnostic assays. The candidate will independently lead assay development projects while collaborating with cross-functional teams, both within and outside the department, under general supervision.

Requirements

Ph.D. in molecular biology, biochemistry, genetics, or related discipline.
Minimum of 3 years of hands-on experience in sequencing workflow and assay development, preferably in an industrial or clinical diagnostic setting.
Proven expertise in tissue FFPE, fine needle biopsy, and/or cfDNA sequencing workflows.
Strong understanding of molecular assay development and validation principles.
Proficiency in molecular biology techniques such as PCR, qPCR, NGS, and nucleic acid extraction.
Experience with data analysis tools and software relevant to NGS.
Excellent problem-solving skills and attention to detail.
Strong communication and collaboration skills.

Nice To Haves

Agility in learning new concepts and skills and applying them to R&D work.
Experience in R&D assay transfer to operation.
Experience working in a regulated environment (e.g., CLIA, CAP).
Familiarity with automation platforms and liquid handling systems.

Responsibilities

Lead and contribute to the design, development, and optimization of molecular assays, with a focus on tissue and cfDNA workflows.
Develop DNA library preparation chemistry and workflow for FFPE tissue samples.
Refine chemistry and workflows for cell-free DNA library preparation.
Design and execute experiments, analyze data, and interpret results to support assay performance and troubleshooting.
Define assay performance metrics and collaborate with the validation team on designing verification & validation study.
Collaborate cross-functionally with bioinformatics, validation, automation, and clinical teams to ensure robust assay development, validation and transfer.
Maintain detailed records of experimental procedures, results, and protocols in accordance with regulatory and quality standards.
Present findings and updates to internal stakeholders and contribute to technical reports and publications.
Keep up to date with emerging technology and scientific trends, and contribute to new assay improvement or development ideas.
Evaluate assay improvement and novel ideas through experimental approach.
Adhere to the Code of Conduct as outlined in the Baylor Genetics Compliance Program.
Perform other job-related duties as assigned