Principal Technology Strategist, Lab Systems

Natera

2d • Remote

About The Position

The Principal Technology Strategist for Lab Systems is an enterprise-level technical leader responsible for the architectural vision and "north star" of the informatics platforms that power our global clinical laboratories. This role focuses on operational excellence through technology, ensuring that our software ecosystem is a competitive advantage rather than a bottleneck.
This strategist will define how we modernize and integrate the full lifecycle of a clinical sample—spanning order management, sample accessioning, high-throughput tracking, and end-to-end workflow orchestration. Beyond the "wet lab workflows," this role is accountable for the seamless technical integration between laboratory systems and the broader commercial ecosystem, including Order Intake & Electronic Medical Records (EMR), Revenue Cycle Management (RCM), and Customer Experience (CX) platforms.
In the first 90 days, the Strategist will map the "Order-to-Result" technical journey, identifying friction points in sample triage and data handoffs. They will establish credibility with Lab Operations and Commercial leadership by proposing a high-level integration framework that reduces manual touchpoints.
Within the first year, the Strategist will have designed and begun the rollout of a unified orchestration layer that standardizes how Oncology, Women’s Health, and Organ Health samples move through our facilities. Success will be measured by improved “sample journey”, reduced turnaround times (TAT), and a scalable architectural blueprint that allows new assays to be onboarded with minimal custom engineering.

Requirements

• 10+ years of experience in enterprise software architecture, with a heavy emphasis on Laboratory Informatics, LIMS, or Healthcare IT.
• Demonstrated success designing systems that manage high-volume sample lifecycles (Accessioning, Triage, and Orchestration).
• Proven expertise in Enterprise Integration Patterns, specifically connecting clinical lab systems to EMRs and RCM/Billing platforms.
• Deep understanding of the "Order-to-Cash" technical journey in a diagnostic or medical device environment.
• Strong executive presence with the ability to influence Lab Operations, Commercial, and Engineering stakeholders.

Nice To Haves

• Familiarity with FDA-regulated software and Computer System Validation (CSV) for complex integrations.
• Background in Genomics or Oncology, specifically handling the complexities of "Dry Lab" data pipelines and "Wet Lab" physical constraints.

Responsibilities

• Design the architectural framework for next-generation sample accessioning and triage, utilizing automation and intelligent routing to minimize manual data entry and sample handling errors.
• Define the strategy for End-to-End Workflow Tracking, ensuring real-time visibility of sample status from kit activation through wet-lab processing to final clinical reporting.
• Lead the modernization of Workflow Orchestration, moving away from static, hard-coded paths toward a dynamic, metadata-driven engine that supports complex branching across multiple lab sites.
• Partner with Lab Ops to identify "automation-first" opportunities, ensuring software and robotics (Hamilton, Tecan, etc.) are deeply integrated for maximum throughput.
• Architect the "Digital Bridge" between Laboratory Information Systems (LIMS) and commercial platforms, ensuring robust, bi-directional data flow with EMR/EHR systems and Provider Portals.
• Collaborate with Customer Experience (CX) teams to ensure lab data is surfaced to patients and providers through modern, API-driven interfaces.
• Lead the technical strategy for "Order Triage," ensuring complex clinical orders are validated and routed correctly across diverse business units (Oncology, MRD, WH).
• Lead deep-dive technical evaluations of third-party LIMS, Middleware, and RCM integration engines, weighing them against the long-term benefits of our homegrown informatics ecosystem.
• Develop the technical roadmap for transitioning legacy, siloed databases into a unified enterprise data fabric that supports both clinical operations and downstream R&D.
• Act as the lead technical advisor to the SVP and a mentor to the 400-person engineering organization, fostering a culture of "Systems Thinking."
• Bridge the gap between the "Physical Lab" and "Digital Software," ensuring that architectural decisions account for the realities of clinical scale and regulatory rigor (CLIA/CAP/FDA).

Benefits

• Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents.
• Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits.
• Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more.
• We also offer a generous employee referral program!

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Education Level: No Education Listed