Principal Scientist – Translational Science – Neurodegeneration

GSK•Upper Providence, PA

1d•Onsite

About The Position

As Principal Scientist in the Translational Unit within the Translational and Development Sciences (TDS) team, you will play a critical role in bridging preclinical target and asset validation and early clinical proof of concept studies by designing and performing translational assays in human-derived cells, tissues, biofluids, and surgical discard organs. This is a lab-based bench scientist position located at the GSK – Upper Providence, Pennsylvania (USA) site. This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following… Design, execute, and analyze laboratory experiments to advance scientific understanding and support drug discovery. Apply hands-on expertise in several of the following capabilities: ELISA/MSD/Quanterix, Western/JESS, flow cytometry, gene expression analysis, iPSC cell culture, and emerging technologies. Maintain accurate and detailed laboratory records in alignment with data integrity expectations and ensure compliance with all relevant protocols and safety guidelines. Effectively trouble-shoot assays and, when necessary, develop alternative approaches. Work closely with preclinical statistics and other relevant teams to ensure robust study design of experiments. Present findings to internal teams, stakeholders, and governance in a balanced, clear, and precise manner. Work closely with key partners to design, optimize, and execute studies to strengthen target-disease hypotheses and provide evidence for GSK translational pillars by using human ex vivo samples. Provide technical and disease input into the translational strategy for one or more projects and influence project direction through interpretation and integration of relevant project and other data. Utilize a growing internal and external network to build translational expertise in technology and disease areas; act as a go-to expert on specific technologies and/or disease mechanisms in neurodegeneration. Identify and progress collaborations with external partners, including academic institutions and contract research organizations, to leverage expertise and resources to support translational studies. Stay up to date with the latest scientific literature and emerging technologies relevant to translational research. Ensure compliance with all applicable laws, regulations, and ethical standards in the conduct of translational research. Foster a culture of innovation, collaboration, and continuous learning within the translational research team and across the organization.

Requirements

PhD in a relevant scientific discipline (e.g., Neuroscience, Immunology, Molecular Biology, Genetics, or related field).
4+ years' experience in translational science, biomarker development, and drug discovery.
Experience in neurodegeneration disease area.
Hands-on experience in several of the following technical capabilities: bioassay development and analysis (ELISA/MSD/Quanterix), flow cytometry, DNA and RNA sequencing technologies, iPSC cell culture, and emerging technologies.
Experience in human systems using cell and molecular biology, bioassays, and analytic methods.
Experience in neurodegenerative disease mechanisms and pathways and the ability to apply this knowledge to translational research and biomarker development.
Experience with scientific innovation as evidenced by effective support of drug discovery projects, peer-reviewed publications, conferences, internal reports, technical evidence documents or patents.

Nice To Haves

Excellent problem-solving skills and ability to critically analyze scientific data.
Familiarity with bioinformatics tools for the interpretation of large-scale datasets.
Strong written and verbal communication skills, with the ability to effectively present scientific findings to multidisciplinary internal and external stakeholders in a balanced, clear, and precise manner.
Proven ability to balance priorities across multiple objectives, meeting timelines while maintaining attention to detail and high-performance standards.
Able to independently define strategic approach to tackle specific project or department goals.
Ability to work independently as well as collaboratively in a team-oriented environment.
Resourcefulness to access cutting-edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities.
Experience in the design and execution of biomarker-driven clinical trials and the development of companion diagnostics.
Knowledge of regulatory guidelines and compliance requirements related to translational research and clinical development.

Responsibilities

Design, execute, and analyze laboratory experiments to advance scientific understanding and support drug discovery.
Apply hands-on expertise in several of the following capabilities: ELISA/MSD/Quanterix, Western/JESS, flow cytometry, gene expression analysis, iPSC cell culture, and emerging technologies.
Maintain accurate and detailed laboratory records in alignment with data integrity expectations and ensure compliance with all relevant protocols and safety guidelines.
Effectively trouble-shoot assays and, when necessary, develop alternative approaches.
Work closely with preclinical statistics and other relevant teams to ensure robust study design of experiments.
Present findings to internal teams, stakeholders, and governance in a balanced, clear, and precise manner.
Work closely with key partners to design, optimize, and execute studies to strengthen target-disease hypotheses and provide evidence for GSK translational pillars by using human ex vivo samples.
Provide technical and disease input into the translational strategy for one or more projects and influence project direction through interpretation and integration of relevant project and other data.
Utilize a growing internal and external network to build translational expertise in technology and disease areas; act as a go-to expert on specific technologies and/or disease mechanisms in neurodegeneration.
Identify and progress collaborations with external partners, including academic institutions and contract research organizations, to leverage expertise and resources to support translational studies.
Stay up to date with the latest scientific literature and emerging technologies relevant to translational research.
Ensure compliance with all applicable laws, regulations, and ethical standards in the conduct of translational research.
Foster a culture of innovation, collaboration, and continuous learning within the translational research team and across the organization.