Principal Scientist, Non Viral Attribute Sciences

Bristol Myers Squibb•Seattle, WA

About The Position

Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us . At Bristol Myers Squibb we are reimagining the future of cell therapy. With our bold ambition, backed by a best-in-the-industry team and long-term commitment, we are leading the way to unlock the full promise of cell therapy as we strive to put more patients on the path to a cure. If you are ready to challenge yourself, accelerate your career, and give new hope to patients, there’s no better place than here at BMS with our Cell Therapy team. Position Summary: As a Principal Scientist with Cell Therapy Analytical Development, this energetic, collaborative, and motivated individual will establish and lead Non-Viral Attribute Science. This person will be responsible for the creation of a holistic analytical toolbox used to interrogate and discover quality attributes of non-viral gene editing drug substances including Ribonucleoprotein complexes, RNA species, and LNPs. Importantly, they will also assess attribute impact on downstream edited cell function. This position will help establish core expertise and knowledge within CTAD to support next generation cell therapy modalities.

Requirements

Ph.D. in Immunology, Cell/Molecular Biology, Analytical Chemistry, Biomedical Engineering or related discipline with demonstrated track/record of experience leading teams to achieve objectives in industrial and/or academic settings (5+ years for Ph.D)
Profound understanding of RNA and RNP biology especially in cell therapy applications
Experience characterizing function of RNA and RNP reagents in primary cells (primary cell culture, gene expression by flow or molecular readout, potency and other functional assays)
Familiarity with analytical methods used to characterize non-viral drug substances (ion exchange chromatography, size exclusion chromatography, icIEF, FRET, protein and nucleic acid quantitation, peptide mapping)
Hands-on experience working with a non-viral gene delivery platform
Motivation and drive to acquire new skills and knowledge
Willingness to work in a regulated industrial environment
Excellent verbal, written, and oral communication skills

Nice To Haves

Experience with automation and high throughput analytical solutions is desired

Responsibilities

Hands on development of robust analytical methods to support internal process development of non-viral materials, and their use thereof in cells
Provide technical and scientific subject matter expertise to drive early non-viral development strategies
Assist in the assessment of the analytical readiness of CDMO/CRO’s
Identify and define Critical Quality Attributes (CQA) of non-viral drug substances
Identify key measures of drug substance function in primary and immortal cells
Contribute to the authorship of SOPs, technical reports and regulatory submission documents (including S.3.1 sections)
Present and discuss findings to stakeholders and senior leadership
Collaborate cross-functionally with CTAD peers, research, process development and CMC to support early platform assessment efforts

Benefits

Health Coverage: Medical, pharmacy, dental, and vision care.
Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

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