Principal Scientist, In Vivo Pharmacology

Merck • Boston, MA

1d • Hybrid

About The Position

The Discovery Quantitative Biosciences (QB) in vivo Pharmacology team at Boston is looking for an initiative-taking and experienced Principal Scientist with a strong background in Immunology and In Vivo Pharmacology. The successful candidate is expected to drive scientific excellence in the implementation of inflammation/autoimmune model development, in vivo PK/PD and efficacy studies while serving as a key intellectual contributor in the conception and execution of discovery projects. The role will involve significant interaction and collaboration among various functional groups in a highly matrix system and with external partners.
The successful candidate will lead in vivo scientists to:
Perform experiments using preclinical species to support the discovery and clinical development of novel immunology compounds.
Manage external studies at CROs and academic collaborators including monitoring study execution and ensuring finalization of study reports within set timelines.
Manage a group of in vivo scientists, providing guidance, mentorship, accountability, and professional development opportunities.
Serve as a scientific leader in the Quantitative Biosciences (QB) department at Boston, partnering and aligning with our global, network-wide organizational objectives, and ensuring that we remain at the forefront of drug discovery.
Represent the QB/Pharmacology functional area at therapeutic area governance forums, program teams, due diligence exercises, and/or cross-functional teams as needed.
Foster a culture of innovation and continuous improvement within the QB/Pharmacology team, driving the development and adoption of new methodologies and technologies.
Ensure compliance with company established practices and procedures, including laboratory notebooks, computer files, quality and regulatory guidelines, and safety standards.

Requirements

• PhD in Immunology, Pharmacology, Biology, Biotechnology, Molecular and Cell Biology, Biochemistry, Bioengineering, or related STEM field with 7+ years of industry / biotech experience in immunology drug discovery, or an MS with 10+ years of experience, or a BS with 14+ years of experience.
• Experience using preclinical models to evaluate the in vivo pharmacology of novel immunology and/or inflammation drugs.
• Proven managerial/supervisory experience with a track record of training, developing talent, and mentoring team members in the field of Immunology/pharmacology and drug discovery.
• Proficiency in complex problem-solving and the ability to influence strategy across organizational boundaries.
• Strong skills in strategic thinking, effective communication, collaboration, balanced risk-taking, and a relentless pursuit of excellence.
• Accountability
• Adaptability
• Assay Development
• Autoimmune Diseases
• Biopharmaceutical Industry
• Cell Culture Techniques
• Clinical Immunology
• Communication Strategy Development
• Detail-Oriented
• Drug Discovery Process
• Ethical Compliance
• Immunology
• Immunotherapy
• Inflammatory Diseases
• Innovation
• In Vivo Models
• In Vivo Pharmacology
• Leading Project Teams
• Mouse Models
• Persuasion
• Translational Pharmacokinetics and Pharmacodynamics (PKPD)

Responsibilities

• Perform experiments using preclinical species to support the discovery and clinical development of novel immunology compounds.
• Manage external studies at CROs and academic collaborators including monitoring study execution and ensuring finalization of study reports within set timelines.
• Manage a group of in vivo scientists, providing guidance, mentorship, accountability, and professional development opportunities.
• Serve as a scientific leader in the Quantitative Biosciences (QB) department at Boston, partnering and aligning with our global, network-wide organizational objectives, and ensuring that we remain at the forefront of drug discovery.
• Represent the QB/Pharmacology functional area at therapeutic area governance forums, program teams, due diligence exercises, and/or cross-functional teams as needed.
• Foster a culture of innovation and continuous improvement within the QB/Pharmacology team, driving the development and adoption of new methodologies and technologies.
• Ensure compliance with company established practices and procedures, including laboratory notebooks, computer files, quality and regulatory guidelines, and safety standards.

Benefits

• The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
• We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree