Principal Scientist, In Vivo Pharmacology, Oncology Discovery Biology

Bristol Myers Squibb

4d•Onsite

About The Position

In the role as Principal Scientist within Oncology Discovery Pharmacology and In vivo Biology, the ideal candidate will: Function as Pharmacology lead as well as provide support for T cell engager drug discovery programs. Working closely with project teams and key stakeholders, lead the development of in vivo strategies from target concept to Proof of Concept in patients, applying scientific and technical skills and functional knowledge to complex projects. Demonstrate critical thinking to address project challenges and independently drive the program forward with solution-oriented mindset. Characterize drug candidates in vivo as part of the lead selection process, utilizing strong foundational knowledge of building PK, PD, BioD and efficacy relationship in vivo and employ innovative approaches and novel technologies to advance research molecules towards development candidate selection and IND. Identify and develop state of the art in vivo models, experimental protocols and relevant assays. Work with cross-functional teams participate in development and implementation of program strategy, including integrating in vivo pharmacology strategy with toxicology and translational strategies to support regulatory filings. Design, independently execute and deliver experiments with comprehensive high quality data sets to drive decision making. Interpret results of complex experiments. Use relevant information, technology and resources, contributing to complex team problem resolution and goals. Proactively foster relationships across disciplines to facilitate decision making process. Participates in the decision-making process for completion of team goals and communicates program strategy and timelines to Project teams. Prepare and present comprehensive technical or project updates in team meetings and other forums. Leads initiatives related to development of new approaches / technologies within T-Cell engager strategy. Encourages use of experimental / innovative approaches within group.

Requirements

Bachelor’s Degree 8+ years of academic and / or industry experience
Master’s Degree 6+ years of academic and / or industry experience
Ph.D. or equivalent advanced degree in the Life Sciences 4+ years of academic and / or industry experience

Nice To Haves

PhD immunology, cancer biology or relevant biological science with 4+ years of relevant industry experience in in vivo pharmacology and a comprehensive expertise in oncology drug discovery, T cell biology and immuno-oncology.
Industry experience with a proven track record of independently driving in vivo strategy for immune cell engagers, including CD3 T cell engagers as cancer therapeutic.
Demonstrated ability to independently develop focused in vivo strategies and utilizing PK/PD/efficacy data to drive discovery, optimization, and characterization of CD3 T-cell engagers is required.
Demonstrated leadership in developing and deploying novel in vivo models to enable immune cell engager, including T-cell engagers, drug discovery and translational research is required.
Hands-on experience using various cell line and PDX mouse models, humanized mouse models, admixture xenografts, orthotopic models to execute in vivo workflows enabling candidate selection for early clinical development is highly desired.
Demonstrated expertise in utilizing relevant pharmacodynamic assays such as MSD ELISAs, Luminex and immune profiling by flow cytometry.
Proficient in developing FACS panels, executing ex-vivo profiling approaches and analyzing FACS datasets.
Familiar with PET/CT, IVIS and other novel imaging approaches, data analysis methods for evaluating Biodistribution of biological modalities.
Excellent interpersonal and communication skills with the ability to interact effectively with internal and external colleagues are required.
Competitive candidates are expected to have a strong track record of independent and innovative research.

Responsibilities

Function as Pharmacology lead as well as provide support for T cell engager drug discovery programs.
Working closely with project teams and key stakeholders, lead the development of in vivo strategies from target concept to Proof of Concept in patients, applying scientific and technical skills and functional knowledge to complex projects.
Demonstrate critical thinking to address project challenges and independently drive the program forward with solution-oriented mindset.
Characterize drug candidates in vivo as part of the lead selection process, utilizing strong foundational knowledge of building PK, PD, BioD and efficacy relationship in vivo and employ innovative approaches and novel technologies to advance research molecules towards development candidate selection and IND.
Identify and develop state of the art in vivo models, experimental protocols and relevant assays.
Work with cross-functional teams participate in development and implementation of program strategy, including integrating in vivo pharmacology strategy with toxicology and translational strategies to support regulatory filings.
Design, independently execute and deliver experiments with comprehensive high quality data sets to drive decision making.
Interpret results of complex experiments.
Use relevant information, technology and resources, contributing to complex team problem resolution and goals.
Proactively foster relationships across disciplines to facilitate decision making process.
Participates in the decision-making process for completion of team goals and communicates program strategy and timelines to Project teams.
Prepare and present comprehensive technical or project updates in team meetings and other forums.
Leads initiatives related to development of new approaches / technologies within T-Cell engager strategy.
Encourages use of experimental / innovative approaches within group.

Benefits

Health Coverage: Medical, pharmacy, dental, and vision care.
Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

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