Scientist, Oligo Discovery Biology

GSK•Cambridge, MA

About The Position

Scientist, Oligo Discovery Biology At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together. Find out more: Our approach to R&D This is an exciting opportunity to join GSK as a Scientist on the growing Oligo Discovery Biology Team. In this new role, you will lead the design, implementation, and optimization of automation systems to support in vitro screening operations, including oligo platform and portfolio projects at Cambridgepark Drive. You’ll collaborate with cross-functional teams to deliver innovative solutions that enhance efficiency, reliability, and compliance. We value candidates who are proactive, detail-oriented, and passionate about driving continuous improvement in a dynamic environment.

Requirements

MS with 3+ or BS with 5+ years’ experience in molecular or cell biology or related field with a concentration in automation.
Experience in mammalian cell culture techniques, including plating and transfection of nucleic acids in high-throughput formats (96-well and 384-well plates).
Demonstrated experience in cell and molecular biology and techniques (e.g. RNA/DNA isolation, transfection, PCR/qPCR, ELISA, Western Blot, gel electrophoresis, etc.).

Nice To Haves

Industry experience in a biotech or pharmaceutical setting is preferred
Experience in oligonucleotide therapeutics (e.g. ASO, siRNA, SSO, RNA Editors) is a plus.
Proven ability to deliver small Automation based projects on time.
Proven ability to train other scientists with Automation Equipment.
Experience with a wide range of Automation Equipment/Software: Tecan Fluent/Fluent Control, HighRes Bio/CellarioScheduler, Certus Flex.
Familiarity with Mosaic, Benchling (LIMS), Jira is preferred.
Independent individuals with strong initiative and ability to troubleshoot challenges and implement new solutions.
Excellent written and verbal communication skills, attention to detail, organizational skills, and the ability to collaborate effectively with a team are required.

Responsibilities

Independently design, execute, and troubleshoot high throughput cell-based assays to support oligo platform and portfolio projects.
Miniaturize (384-well) and adapt cell-based assays into automated workflows.
Establish new screening workflows and draft SOPs in support of new programs.
Analyze and present data, recommending courses of action based on datasets.
Lead and participate in discussions with cross functional teams to support lead discovery.
Serve as the technical expert for site automation equipment in the Oligo Discovery Biology team and cross-functional teams, as well as provide day-to-day automation support.
Own and deliver small Automation projects including cost improvement, change control, planning, validation and delivery.
Ensure Automation Equipment is maintained and installed to meet site requirements.
Train other scientists in the team with new assays and automation.
Be a key member of Oligo Discovery Biology team and serve as a strong representative on interdisciplinary project teams.