Associate Scientist - In Vivo Pharmacology

Bristol Myers Squibb • San Diego, CA

3d • Onsite

About The Position

The Protein Homeostasis Thematic Research Center (TRC) at BMS is a fundamental Oncology research engine delivering oncology and hematology therapeutics to patients. The TRC has a major focus on exploiting BMS’ expertise in protein degradation to discover and develop therapies aimed at tumor intrinsic vulnerabilities and mechanisms of resistance to existing cancer therapeutics. This focus on protein degradation allows us to attack protein classes that were previously deemed undruggable. The Pharmacology group within the Protein Homeostasis TRC at BMS San Diego provides in vivo pharmacology support to discovery teams focused on developing small molecules and biologics for oncology and immune-oncology. As an integral part of discovery programs, the group supports lead identification through in vivo model screening and mechanism-of-action studies, develops and validates animal disease models, identifies pathway biomarkers, and establishes clinically relevant endpoints to assess efficacy. Collaboration with DMPK, Exploratory Toxicology, and Translational Development is central to our work, and we contribute preclinical data to inform clinical development plans.

Position Summary: We are seeking a motivated Associate Scientist with broad experience in pharmacology and drug discovery for both small and large molecules. The successful candidate will work collaboratively in a multidisciplinary environment, taking responsibility for experiment design, planning, and execution. Key duties include interpreting and presenting in vivo data, conducting sample and endpoint analyses (ELISA, Western blot, Jess, qPCR, IHC), and preparing protocols and reports. The role requires independent work, technical expertise, and contributions to project decisions. Strong communication, self-motivation, innovation, flexibility, and teamwork are essential.

Requirements

• Bachelor’s Degree
• 2+ years of academic and / or industry experience

Nice To Haves

• Bachelor's Degree and 2+ years of academic and / or industry experience with oncology models
• Experience in mammalian cell culture
• Experience in the development of syngeneic and xenograft cancer models
• Proficient in animal handling, dosing (PO, IP, IV, and SC), tumor cell inoculation, data collection and analysis
• Hands-on experience in small animal surgeries, necropsy and tissue and blood collection
• Hands-on experience in evaluating small molecules in animal models
• Experience with small animal imaging modalities (e.g., Xenogen, ultrasound etc.) is a plus.
• Skilled in Western blots, ELISA, MesoScale, IHC, flow cytometry, RNA/DNA extraction, and PCR
• Proficient in Excel, Word, PowerPoint, FlowJo, GraphPad Prism, and Studylog
• Excellent interpersonal, communication, presentation, collaboration, and organizational skills
• Detail-oriented, focused, and able to deliver high-quality data efficiently

Responsibilities

• Develop disease models for oncology and immune-oncology
• Independently design and execute in vivo efficacy and PK/PD experiments to identify drug candidates
• Analyze and interpret data accurately, reporting findings to supervisors and colleagues
• Troubleshoot routine issues and recommend solutions
• Evaluate endpoints from in vivo studies using Western blots, mesoscale, qPCR, etc.
• Write precise protocols and technical reports
• Present data to multidisciplinary discovery teams
• Collaborate with cross-functional team members

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.
• Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Number of Employees: 5,001-10,000 employees