Principal Scientist in Chemical Induced Proximity

St. Jude Children's Research Hospital • Memphis, TN

17h

About The Position

We are seeking a highly motivated and innovative Principal Scientist with specialized expertise in drug discovery to direct our Chemical Induced Proximity Center in the highly collaborative Department of Chemical Biology and Therapeutics. The World’s Brightest Minds Always Innovate At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children. The incumbent will be responsible for driving strategic decisions throughout the various stages of the small molecule drug discovery process focusing on chemically induced proximity platforms. Experience with use of computational tools including Artificial Intelligence (AI) and Machine Learning (ML) in virtual screening, small molecule design and optimization is preferred. Set up the chemistry strategy for projects and advance drug discovery programs by collaboratively interacting cross-functionally within departmental collaborative centers and various departments at the institution. Lead and manage a team of scientists and large-scale, multidisciplinary projects through proactive research collaboration, and provide direction in specific area of expertise. Contribute to recruiting and growing the team, guiding and mentoring junior staff. Stay at the forefront of induced proximity platforms, including but not limited to PROTACs, molecular glues, and other bifunctional or allosteric modulators. Evaluate new technologies, chemical tools, and screening platforms that can accelerate the development of proximity-based therapeutics. Design and optimize focused chemical libraries to identify hits, leads, and drug candidates that induce selective protein interactions and cellular phenotypic changes. Maintain collaborative partnerships while ensuring recognition on collaborating publications and patents. Lead and manage a number of contract research organizations (CRO) and external chemistry partners across the globe. Oversee structure-activity relationship (SAR) studies to enhance potency, selectivity, and drug-like properties of candidate molecules. Lead efforts to improve the pharmacokinetic, pharmacodynamic, and toxicological profiles of compounds in collaboration with ADMET and DMPK teams. Serve as functional expert in due diligences for assets in-licensing and discovery partnerships. Responsible for leading publication efforts in high-impact scientific journals. Experience in drug discovery in Pharma/Biotech industry highly preferred. Experience with computational design or AI/ML preferred. PhD with management experience preferred. This is a senior leadership role with a focus on advancing cutting-edge drug discovery programs for childhood catastrophic diseases using the latest approaches in proximity-based targeting. Specifically, based on the mechanistic basis of disease, our goal is to develop unique chemical approaches (protein degraders, synthetic gene regulators and/or functional effectors) to degrade or manipulate targets relevant to pediatric oncology, neurodegenerative disorders, and sickle cell disease.

Requirements

• Bachelor's degree in relevant scientific area is required.
• Fifteen (15) years of relevant work experience is required with a Bachelor's degree.
• Thirteen (13) years of relevant work experience is required with a Master's degree.
• Ten (10) years or relevant work experience is required with a PhD.

Nice To Haves

• Experience with use of computational tools including Artificial Intelligence (AI) and Machine Learning (ML) in virtual screening, small molecule design and optimization is preferred.
• Experience in drug discovery in Pharma/Biotech industry highly preferred.
• Experience with computational design or AI/ML preferred.
• PhD with management experience preferred.

Responsibilities

• Driving strategic decisions throughout the various stages of the small molecule drug discovery process focusing on chemically induced proximity platforms.
• Setting up the chemistry strategy for projects and advance drug discovery programs by collaboratively interacting cross-functionally within departmental collaborative centers and various departments at the institution.
• Leading and managing a team of scientists and large-scale, multidisciplinary projects through proactive research collaboration, and provide direction in specific area of expertise.
• Contributing to recruiting and growing the team, guiding and mentoring junior staff.
• Staying at the forefront of induced proximity platforms, including but not limited to PROTACs, molecular glues, and other bifunctional or allosteric modulators.
• Evaluating new technologies, chemical tools, and screening platforms that can accelerate the development of proximity-based therapeutics.
• Designing and optimizing focused chemical libraries to identify hits, leads, and drug candidates that induce selective protein interactions and cellular phenotypic changes.
• Maintaining collaborative partnerships while ensuring recognition on collaborating publications and patents.
• Leading and managing a number of contract research organizations (CRO) and external chemistry partners across the globe.
• Overseeing structure-activity relationship (SAR) studies to enhance potency, selectivity, and drug-like properties of candidate molecules.
• Leading efforts to improve the pharmacokinetic, pharmacodynamic, and toxicological profiles of compounds in collaboration with ADMET and DMPK teams.
• Serving as functional expert in due diligences for assets in-licensing and discovery partnerships.
• Responsible for leading publication efforts in high-impact scientific journals.

Benefits

• View all the benefits offered including Medical & Prescription Drug Plans, Dental Plan, Vision Plan, Financial Security, Retirement Plan, Living Well - Employee Wellness Program, Time Off Programs, Educational Benefits, Family Friendly Benefits, and Benefits Unique to St. Jude.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Number of Employees: 5,001-10,000 employees