Principal Associate Scientist, Translational Pathology
About The Position
About This Role The Translational Pathology group at Biogen, part of Biomarkers and Systems Biology in Research, is seeking a highly motivated and talented scientist to join a dynamic pathology team engaged in human disease translational research and drug development. The scientist will employ cutting-edge histopathologic techniques to develop innovative multiplexed assays for the analysis of human tissues and translational models. As part of a collaborative scientific Team, the scientist will validate/discover molecular targets/pathways. We are looking for an individual that has demonstrated forward-thinking, creativity and a passion to develop novel therapeutics. What You’ll Do Utilize advanced automation for multiplex assay development and troubleshooting across immunohistochemistry and in situ hybridization platforms Support histologic aspects of spatial omics studies Seek out new techniques and technologies to support clinical and non-clinical studies Perform routine histology procedures, including trimming, processing, embedding, sectioning, H&E and special stains as needed on both FFPE and frozen tissue specimens Manage daily laboratory operations including but not limited to equipment maintenance and consumable purchasing Manage histologic aspects of studies performed at external vendors
Requirements
- BS or MS degree in Biological Sciences and a minimum 5 years of relevant histology or pathology laboratory experience
- Demonstrated ability to handle several projects at any given time and to work successfully and collaboratively on teams
- Excellent tissue handling techniques, including trimming, processing, embedding tissue specimens, sectioning, staining, cover slipping and other routine operations of a histology lab
- Extensive hands-on experience in histology assays, mulitpleded immunohistochemistry and in-situ hybridization techniques
- Working knowledge of Ventana and Leica automated IHC / ISH instrumentation
Nice To Haves
- Experience supporting tissue-based omics studies including single-cell transcriptomics, spatial transcriptomics and/or spatial proteomics
- Experience with image analysis software
- Prior industry experience
Responsibilities
- Utilize advanced automation for multiplex assay development and troubleshooting across immunohistochemistry and in situ hybridization platforms
- Support histologic aspects of spatial omics studies
- Seek out new techniques and technologies to support clinical and non-clinical studies
- Perform routine histology procedures, including trimming, processing, embedding, sectioning, H&E and special stains as needed on both FFPE and frozen tissue specimens
- Manage daily laboratory operations including but not limited to equipment maintenance and consumable purchasing
- Manage histologic aspects of studies performed at external vendors
Benefits
- Medical, Dental, Vision, & Life insurances
- Fitness & Wellness programs including a fitness reimbursement
- Short- and Long-Term Disability insurance
- A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
- Up to 12 company paid holidays + 3 paid days off for Personal Significance
- 80 hours of sick time per calendar year
- Paid Maternity and Parental Leave benefit
- 401(k) program participation with company matched contributions
- Employee stock purchase plan
- Tuition reimbursement of up to $10,000 per calendar year
- Employee Resource Groups participation
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What This Job Offers
Job Type
Full-time
Career Level
Principal
