Postdoctoral Fellow-MSH-12907-056
About The Position
Details of Research Project: Dr. Hao Xiang will perform the following research projects under the mentoring of Dr. Tianliang Sun: Mechanism of boosting of liver regeneration to reverse MASH. Combining multiomics data profiling, mouse genetics, histology, intravital imaging and organoid systems, we will systemically analyze the mechanism of inflammation resolution, lipid metabolism and fibrosis regression events upon the deletion of ZNRF3 and RNF43. The plasticity of biliary epithelial cells during ductular reaction. We aim to dissect the cell heterogeneity of biliary epithelial cells during liver injuries and the key signaling pathways that involved in regeneration and pathogenesis via various mouse genetic and injury models and organoid cultures. Principles of liver zonation regulation and how zonation play a role in liver diseases
Requirements
- PhD degree in life science
- Training in Biomedical Science and hands on experiments in mouse genetics, molecular and cellular biology, and biochemistry.
Responsibilities
- Mouse handling and monitoring
- organoid culture
- multiomicas data analysis
- histology and tissue processing
- IF staining
- image J based cell and tissue quantification
- microscope imaging in fixed tissue and in live mouse
- buffer preparation and lab maintenance
- genotyping PCR
- data recording and analysis
- presentation in meetings and work in progress.
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What This Job Offers
Education Level
Ph.D. or professional degree
Number of Employees
5,001-10,000 employees
