The researcher will be engaged in translational cancer research projects focused on regulators of growth, survival and drug resistance of breast and other cancers, as well as their microenvironment, especially immune effectors. The researcher will use a broad range of approaches (genetic, cell biological and in vivo modeling) to understand how breastcancers, particularly triple negative breast cancers, resist chemotherapy treatments and metastasize. The projects also examine novel mechanisms that contribute to the growth and metastases of triple negative breast cancers. The researcherwill utilize patient-derived xenograft models of breast cancer and organoid cultures to screen and validate novel therapeutic strategies in collaboration with chemical biologists. The researcher will also study how the immunemicroenvironment regulates response of breast and other cancers to chemotherapy/targeted therapies. The researcher will be expected to design and conduct experiments, be responsible for accurate record keeping and contribute to overallmaintenance of the laboratory. Background in cancer cell biology/models, genetics, molecular biology, biochemistry, or immunology required. Experience with mouse tumor models and related procedures (handling, tumor cell injection, flow cytometry, mouse surgical procedures, IVIS imaging) strongly preferred Ph.D or MD/PhDrequired with at least two years of laboratory experience.
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Job Type
Full-time
Education Level
Ph.D. or professional degree