Postdoctoral Fellow-MSH-32076-165
About The Position
The Ferraride de Andrade Laboratory is seeking highly motivated postdocs to lead the B7-H6 project. In immunology, abnormal self refers to the ability of natural killer (NK) cells to recognize and kill virus infected or malignant cells. However, the self-induced antigens can be shed from the cell surface to enable immune escape. We, therefore, generated novel antibodies that inhibit the shedding in a highly specific manner, to promote NK cell-driven immune surveillance. To enable in vivo studies, we also generated a novel mouse strain that recapitulates key features of a human immune mechanism against the abnormal self. This project will test the hypothesis that antibody-mediated inhibition of self-induced antigens promotes NK cell-driven tumor immunity in vitro and in vivo and help shapes immune compartments. Goals/Outcomes of the Research Project: The research project will generate new mechanistic insights into leukocyte biology and cancer immunology, and it will help develop novel immunotherapies for solid and hematological cancers.
Requirements
- PhD, MD, or MD/PhD
- tissue culture
- leukocyte isolation from human blood samples
- flow cytometry
- qPCR
- maintaining of mouse colony
- mouse genotyping
- in vivo experimentation
- ELISA
- statistical analyses
Responsibilities
- leading the research project
- collaborating with colleagues
- present laboratory meetings and institution-level seminars
- write research articles and fellowships
- help maintain the laboratory operations through equipment maintenance, re-suppling, and inventorying whenever needed.
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What This Job Offers
Job Type
Full-time
Education Level
Ph.D. or professional degree
Number of Employees
5,001-10,000 employees
