Postdoctoral Fellow - Diabetes and Cancer Metabolism Research

City of Hope•Duarte, CA

118d

About The Position

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. A postdoctoral position is open in the laboratory of Yingfeng Deng in the Department of Diabetes and Cancer Metabolism at the City of Hope Beckman Research Institute. The Deng laboratory studies the homeostasis of uridine and its role in metabolism, which provides a new angle for understanding the pathophysiology of obesity, diabetes and cancer. Work in the lab utilizes both genetically engineered mouse models and in vitro systems. A combination of state-of-the-art surgical, genetic, cellular, biochemical, imaging, and metabolic flux approaches is currently used in the lab. Following up with the new paradigm revealed about uridine metabolism by Drs. Deng and Scherer (Science, 2017), the Deng lab is currently focusing on three areas: 1) the role of uridine in the progression of obesity and diabetes. 2) the physiology of uridine in bile and nutrient absorption. 3) the regulation of uridine homeostasis by ER stress and its relevance to breast cancer. We seek an independent and highly motivated candidate interested in studying the molecular, cellular, and metabolic mechanisms leading to obesity, diabetes, and cancer. Expertise in using mouse models to study metabolic diseases is preferred.

Requirements

Ph.D. and/or M.D. degree in life or biomedical sciences or a related discipline is required.
Experience in basic molecular biology skills.
Experience in animal models and lipid metabolism.
Experience in metabolomics and liver physiology.