Post-Doctoral Associate

University of Minnesota • Austin, MN

58d • $62,232 - $72,960 • Onsite

About The Position

The overall objective of the lab is to understand the mechanisms modulating resistance to therapy and use the knowledge gained from these studies to develop novel therapies for glioblastoma. To this end, we utilize genome-wide screening to identify molecular modifiers of therapy sensitivity, especially to temozolomide (TMZ). We have already identified over six hundred potential druggable modulators of TMZ resistance. The post-doctoral fellow will perform secondary validation to identify the best candidates and use biochemical and pharmacological strategies to evaluate the mechanisms by which these candidates sensitize TMZ in glioblastoma cells in vitro and in vivo. The employer retains the right to change or assign other duties to this position.

Requirements

• Ph.D., DDS, DVM, MD or equivalent.

Nice To Haves

• Experience in molecular and/or cancer biology.
• Experience in next-generation sequencing, CRISPR/Cas9 technology, and in conducting flank and intracranial efficacy studies in animals (mice).

Responsibilities

• Conduct in vitro and in vivo studies to assess the efficacy of novel therapeutic targets, both alone and in combination with temozolomide and/or radiation.
• Investigate underlying mechanisms of action using a range of biochemical, pharmacological.
• Use shRNA/CRISPR gene-targeting approaches to validate novel targets identified through secondary, custom-designed siRNA library screening.
• Mentor research technologists, students, and/or interns.
• Prepare and contribute to manuscripts for publication.
• Participate in local and national scientific meetings.

Benefits

• Competitive wages, paid holidays, and generous time off
• Continuous learning opportunities through professional training
• Medical, dental, and pharmacy plans
• Healthcare and dependent care flexible spending accounts
• University HSA contributions
• Disability and life insurance
• Employee wellbeing program
• Financial counseling services
• Employee Assistance Program with eight sessions of counseling at no cost

What This Job Offers

• Job Type: Full-time
• Industry: Educational Services
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees