Post Doc (0) - Lawson Lab

University of Massachusetts Medical School • Worcester, MA

54d

About The Position

A postdoctoral position is available in the Lawson Lab at University of Massachusetts Chan Medical School, Department of Molecular, Cell, and Cancer Biology (lawsonlab.umassmed.edu). The Lawson Lab utilizes the zebrafish as a model system to study the development of the circulatory and lymphatic systems. Current projects focus on two areas: Developmental nature of vascular anomalies. Our goal is to determine how developmental defects associated with known mutations in humans result in defective vascular or lymphatic function. Studies include identifying relevant molecular targets, linking cellular mechanisms and defects to disease phenotypes, and small molecule screening to identify therapeutics. Understanding vascular mural cell development. We seek to dissect transcriptional regulatory networks required for pericyte development. We have identified several candidate transcription factors and current efforts focus on genetic analysis of these candidates to determine how they regulate pericyte specification. For all projects, we routinely develop and apply cutting-edge approaches, including conditional genetics, CRISPR-based gene editing, single cell molecular analyses, and in vivo time lapse.

Requirements

• Experience in molecular biology as documented through their publication record
• Technically accomplished as documented by exceptional publication record

Nice To Haves

• Prior expertise in the application of genome editing in model systems is welcome
• General experience with model organisms is preferred
• Applicants must otherwise be highly motivated

Responsibilities

• Determine how developmental defects associated with known mutations in humans result in defective vascular or lymphatic function
• Identifying relevant molecular targets
• Linking cellular mechanisms and defects to disease phenotypes
• Small molecule screening to identify therapeutics
• Dissect transcriptional regulatory networks required for pericyte development
• Genetic analysis of candidate transcription factors to determine how they regulate pericyte specification
• Develop and apply cutting-edge approaches, including conditional genetics, CRISPR-based gene editing, single cell molecular analyses, and in vivo time lapse.

What This Job Offers

• Industry: Educational Services
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees