Post-Doc Research Associate-Bhatt Lab

UNC-Chapel Hill • Chapel Hill, NC

2d

About The Position

The Bhatt Lab at UNC Chapel Hill is seeking motivated, talented and creative scientists with demonstrable bioanalytical expertise to join our team. In our lab, we are advancing precision medicine by studying the gut microbiome which contributes to interindividual variability in drug responses, including efficacy and toxicity. By studying bacterial drug metabolism, we will develop strategies to predict and prevent drug-induced injury and reduce medication side effects, thus promoting public health. The candidate will have a strong background in bioanalytical techniques and method development using a variety of platforms including but not limited to LC-MS/MS, HPLC , etc. The central role for the candidate is in developing assays to quantify metabolites of drug metabolism generated by gut microbes and the host using tandem LC-MS/MS methodology. The candidate will also provide support for method development to the UNC Dept. Of Mass Spectrometry Core laboratory, directed by Dr. Brandie Ehrmann.

Requirements

• Education: Ph.D. in Chemistry, Pharmacology, Analytical Chemistry, and/or a related field, with recent experience in a research laboratory.
• Mass Spectrometry Expertise: Knowledge of modern mass spectrometer equipment and software from various vendors. Recent hands-on experience with mass spectrometry.
• Wet Lab Experience: Proficiency in pipetting, sample extraction, and sample preparation from biological matrices.
• Data Handling: Experience working with large datasets, particularly those derived from mass spectrometry-based analyses.
• Independence & Problem Solving: Demonstrated ability to work independently and solve complex experimental problems.
• Communication Skills: Ability to present research findings clearly and effectively in both written and oral formats. Experience with manuscript preparation and grant writing.
• Training & Mentorship: Proven ability to train and work constructively with diverse individuals, including laboratory personnel.
• Flexibility: Willingness to work occasional long hours as research demands.
• prior wet lab experience in pipetting, sample extraction, and sample preparation from biological matrices techniques preferred.

Nice To Haves

• Designing and performing experiments, analyzing and interpreting data, disseminating research through written (manuscripts, grant applications, poster presentations) and oral presentations at lab meetings, local/national/international conferences.
• Should be able to work with undergraduate students.
• prior wet lab experience required.
• Previous experience working in drug metabolism, intestinal biology/physiology, epithelial biology/physiology, or stem cell biology/physiology.
• Prior experience operating mass spectrometry and liquid chromatography instrumentation.
• Quantitative mass spectrometry experience utilizing tandem mass spectrometers is a significant bonus.

Responsibilities

• Experimental Design & Execution: Design and conduct experiments with a focus on quantitative mass spectrometry. Perform sample extraction and preparation from biological matrices.
• Data Analysis & Interpretation: Analyze and interpret complex data sets, including quantitative mass spectrometry data. Utilize modern mass spectrometry equipment and software.
• Research Dissemination: Prepare and present research findings through written manuscripts, grant proposals, and oral presentations at lab meetings, local, national, and international conferences.
• Mentorship: Work effectively with undergraduate students, providing training and guidance in laboratory techniques and data analysis.
• Equipment Management: Troubleshoot and maintain mass spectrometry and chromatography equipment. Ensure the proper functioning of laboratory instruments.
• Independent Problem Solving: Address and resolve experimental challenges independently. Relate experimental outcomes to the broader research context.
• Protocol Development: Read and interpret published manuscripts and experimental protocols, adapting methods for laboratory use.

What This Job Offers

• Job Type: Full-time
• Education Level: Ph.D. or professional degree
• Number of Employees: 11-50 employees