The Venosa Laboratory (https://pharmacy.utah.edu/pharmtox/faculty/current-faculty/alessandro-venosa.php) is seeking a highly motivated postdoctoral fellow to join our laboratory’s NIEHS funded efforts to study the interplay between resident and infiltrating immune cells in the pathogenesis, progression and resolution of lung inflammation in the healthy and functionally impaired lung. As the main platform to study susceptibility, our group adopts a murine model of inflammatory exacerbations of pulmonary fibrosis triggered by aberrant expression of a clinically relevant mutant of the surfactant protein C gene (https://www.ncbi.nlm.nih.gov/myncbi/alessandro.venosa.2/bibliography/public/). Responsibilities Successful candidates will independently lead projects in the above mentioned areas of emphasis. However, flexibility on the specific project to be developed will be based on individual expertise and scientific interest. Active areas of research include: 1) identification of long-lived myeloid and lymphoid populations central in coordinating tissue remodeling during all phases of mutant SP-C induced exacerbation of pulmonary fibrosis; 2) phenotyping of macrophages, eosinophils, and B cell subsets during air pollution exposure in the healthy, susceptible, and fibrotic lung; and 3) modeling the impact of aging inflammatory cell function. Within the University of Utah, the candidate will have access to state-of-the-art core facilities in transcriptomics, epigenomics, proteomics, and lipidomics, and a highly engaging environment that encourages collaborations between toxicologists, biologists, and physician scientists from the pulmonary and geriatric divisions.
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