Intern – Medicinal Chemistry
About The Position
Cytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction. At Cytokinetics, each team member plays an integral part in advancing our mission to improve the lives of patients. We are seeking tenacious, compassionate, and collaborative individuals who are driven to make a positive impact. At Cytokinetics we are dedicated to supporting the next generation of biotech professionals through our annual Cytokinetics Internship Program. We believe that investing in enthusiastic students and recent graduates brings fresh perspectives and insights to our teams and we take pride in providing opportunities to contribute to meaningful projects. Through our Internship Program we aim to provide a challenging and rewarding experience to build a strong foundation for a career in the biopharmaceutical industry. Project Description Support a hit-to-lead medicinal chemistry project aimed at improving the potency and selectivity of small-molecule inhibitors against a defined biological target Explore structure-activity relationships (SAR) around a lead scaffold to inform synthetic design Evaluate compounds in biochemical and/or cellular assays and data to guide iterative design decisions Assists in optimizing physicochemical and early ADME properties (solubility, stability) under guidance from project scientists
Requirements
- Upcoming 3rd or 4th year PhD student preferred.
- Bachelor’s degree in chemistry required.
- Prior synthetic organic chemistry lab experience strongly required.
- Demonstrated expertise in organic synthesis, chromatographic purification. methods, and compound characterization using modern analytical techniques (NMR, MS, HPLC, etc.).
- Organized, detail-oriented, excellent record-keeping skills, excellent verbal and written communication skills.
- Ability to work independently and perform well in a team environment.
Responsibilities
- Participate in the design, synthesis, purification, and characterization of novel biologically active molecules
- Apply in-silico machine learning models to inform compound design
- Contribute to exploratory research and lead optimization projects, and collaborate closely with colleagues in other groups
- Summarize/interpret data and present findings in research meetings
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What This Job Offers
Career Level
Intern
Number of Employees
251-500 employees
