Senior/Principal Scientist, Medicinal Chemistry

Flagship Pioneering•Cambridge, MA

14h

About The Position

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability? Company Description Expedition Medicines is a privately held, early-stage biotechnology company pioneering the emerging field of Protein Editing. At Expedition Medicines we create small molecules that edit protein structure and function to unlock presently undruggable targets and a broad array of therapeutic modalities. Our platform integrates novel small molecule chemistry and chemoproteomic discovery technologies with Machine Learning (ML) to enable generative design. Expedition Medicines is backed by Flagship Pioneering, bringing their courage, vision, and resources to guide Expedition Medicines from platform validation to patient impact. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us! About the role: We are seeking a Senior / Principal Scientist level medicinal chemist to join our chemistry team at Expedition Medicines. This position will be responsible for the medicinal chemistry strategy and delivery on one or more projects. A candidate with experience collaborating with a machine learning team to deliver against project goals is a plus.

Requirements

PhD in synthetic organic or medicinal chemistry with at least 5 years’ drug discovery experience in pharmaceutical industry or BS/BA in chemistry with at least 10 years’ experience in pharmaceutical industry.
Strong modern synthetic background preferred with knowledge of state-of-the-art organic chemistry methodologies.
Experience managing external chemistry CROs.
Strong communication and interpersonal skills.

Nice To Haves

Experience collaborating with machine learning teams preferred.
Experience with both traditional small molecules and beyond-rule-of-5 therapeutic modalities is a plus.

Responsibilities

Design and deliver medicinal chemistry strategy on project(s).
Optimize small molecules through analysis of biochemical, biological, and ADME assay data.
Manage chemistry CROs for timely delivery of synthetic efforts.
Collaborate with cross-functional teams for project needs in high-paced data-driven environment.
Collaborate with machine learning team for delivery against medicinal chemistry strategy.
Contribute to patent applications and scientific publications.