Executive Director, Commercial Data Strategy and Analytics

Madrigal Pharmaceuticals • Waltham, MA

57d

About The Position

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Position Summary The Executive Director of Commercial Data Strategy and Analytics will be a senior leader responsible for building and scaling Madrigal’s global commercial data ecosystem. This role will own the commercial data vision and analytics roadmap in the short and long-term to enable Rezdiffra’s trajectory to peak performance, while also laying the foundation for future product launches. The role includes oversight of the commercial analytics team, commercial data management team, and cross-functional insight generation across both U.S. and ex-U.S. markets.

Requirements

• Bachelor’s degree in a quantitative, technical, or business discipline (e.g., Data Science, Statistics, Engineering, Computer Science, Economics)
• 15+ years of experience in commercial analytics, data strategy, or operations within pharmaceutical or biotech companies, including global and U.S. markets.
• Proven success building long-term analytics strategies to support brand growth from launch through maturity.
• Deep experience with commercial data integration (hub, SP, claims, CRM), master data management (MDM), and enterprise governance frameworks.
• Proficiency in leading advanced analytics projects & stewarding AI/ML development
• Collaborating with IT on enterprise data infrastructure and compliance alignment.
• Exceptional leadership, stakeholder management, and communication skills.

Nice To Haves

• MBA, MS, or PhD strongly preferred.

Responsibilities

• Define and lead a multi-year commercial data and analytics vision aligned with the long-range brand plan for Rezdiffra and future assets.
• Develop and execute a strategic roadmap to evolve Madrigal’s commercial data capabilities, tools, and infrastructure in phases that match business growth and market complexity.
• Identify and prioritize high-value commercial analytics capabilities to support Rezdiffra’s growth through launch, acceleration, and maturity.
• Commercial champion for advanced AI and data science capabilities (e.g. predictive analytics, advanced analytics, next-best-action engine)
• Own the global commercial data strategy, ensuring scalable integration of specialty pharmacy, hub, claims, CRM, payer, and EMR data to support strategic decision-making.
• Partner closely with IT to ensure commercial data governance is aligned with broader enterprise data architecture, compliance standards, and stewardship protocols.
• Define commercial data quality standards, lineage processes, and best practices for data access, usage, and lifecycle management.
• Support development of and adoption of enterprise predictive-analytics products and translate their outputs into commercial action plans to drive proactive market insights, early signal detection, and strategic scenario planning.
• Own BI development of key dashboards to automate key analytics across the commercial team
• Champion a culture of data experimentation, agility, and continuous learning within the commercial function.
• Oversee the delivery of integrated insights and analytics across global and U.S. markets, enabling cross-regional consistency while accommodating local market nuances.
• Establish a unified global KPI framework to guide strategic planning and executive performance management
• Oversee commercial analytics team that includes brand analytics leadership and support across all the matrix commercial partners: market access, trade, patient access, sales, and marketing
• Manage end-to-end visibility into the patient experience through the integration of specialty pharmacy and hub data, tracking initiation, drop-off, time-to-therapy, and adherence across geographies.
• Support Rezdiffra brand teams with actionable insights to optimize uptake, address access bottlenecks, and shape future growth strategies.
• Build and mentor a world-class team of analysts and data experts with commercial and global scope.
• Lead relationships with key analytics vendors, platform providers, and data aggregators (e.g., IQVIA, Symphony, Veeva, Snowflake, hub/SP partners).
• Ensure flexible, scalable analytics resourcing that evolves with the business.
• Act as a trusted advisor to Commercial, Medical Affairs, IT, and Executive Leadership teams.
• Communicate data-driven insights with clarity and strategic impact, influencing decisions at the highest levels of the organization.

Benefits

• All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create.
• By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.
• Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans.
• We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings.
• In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family.
• The company also provides other benefits in accordance with applicable federal, state, and local laws.
• We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process.

What This Job Offers

• Job Type: Full-time
• Career Level: Executive
• Number of Employees: 501-1,000 employees