Downstream Process Development Co-Op
About The Position
At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients. Job Summary: This role will be responsible for experiment execution in downstream biologics process development. This will include equipment setup, maintenance, processing, and data acquisition in a laboratory setting. Technical report authoring and lab notebook recordkeeping are also critical to this role. The successful candidate will exhibit strong interpersonal skills, technical competence, and a willingness to learn.
Requirements
- Currently enrolled in a biology, chemistry, chemical engineering, bioengineering, molecular biology or related program.
- Familiar with protein biochemistry
- Familiar with general biology lab techniques
- Familiar with statistical analysis and experimental design
- Technical and scientific writing and presentation skills
Responsibilities
- Scale-down and range finding study execution.
- Purification by FPLC of Pilot scale batches.
- Implementation of multiple liquid chromatography types (i.e Affinity, Ion Exchange, HIC)
- Buffer formulation, resin selection and capacity study execution.
- Filter loading and fouling study execution.
- Intermediate stability analysis.
- Formulation and stability study support.
- Protein characterization by A280, SEC, SDS-PAGE and cIEF.
- Statistical data analysis.
- Equipment setup, functional verification and maintenance.
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What This Job Offers
Career Level
Intern
Education Level
No Education Listed
