About The Position

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant® is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn, X (Twitter) and Facebook. The Director, National Accounts – Health Systems is a senior commercial executive responsible for driving substantial national revenue growth and shaping enterprise strategy across Guardant Health’s most complex and strategically significant national IDNs and Organized Customer Groups. This leader serves as executive sponsor to key national accounts, influences enterprise governance at the highest levels, and shapes Guardant’s national health system engagement model. The Director leads complex contracting strategies, enterprise transformation initiatives, and data-driven growth strategies that impact the broader commercial organization. Scope & National Impact Owns Guardant’s largest and most strategically critical national health systems Accountable for significant national revenue targets and long-term profitability Leads multi-state, enterprise-wide adoption strategies Shapes Guardant’s national commercial approach and segmentation strategy Impacts organizational strategy beyond assigned accounts Serves as mentor and strategic advisor across enterprise account teams

Requirements

  • 15+ years progressive leadership in enterprise health system strategy, diagnostics, or population health
  • Demonstrated ownership of large national revenue portfolios
  • Proven board-level presentation capability
  • Extensive experience with complex, risk-based contracting structures
  • Deep expertise in value-based reimbursement and quality metrics
  • Advanced financial and data analytics fluency
  • Demonstrated success leading enterprise transformation initiatives
  • Exceptional executive presence and strategic influence

Responsibilities

  • National Revenue Ownership & Strategic Growth Own and deliver substantial national revenue targets
  • Develop long-term enterprise partnership strategies spanning multiple states
  • Lead enterprise expansion from initial engagement to national standardization
  • Structure and negotiate complex, multi-year and risk-based agreements
  • Ensure forecasting precision and executive-level revenue visibility
  • Executive Sponsorship & Board-Level Engagement Serve as executive sponsor to: Chief Population Health Officers CMOs CFOs Enterprise Strategy Leaders
  • Present Guardant’s enterprise value proposition at governance committees and board-level forums
  • Influence national preventive care and screening strategies at the highest levels
  • Enterprise Change Management & Transformation Leadership Lead large-scale health system transformation initiatives
  • Guide national systems through standardization across diverse geographies
  • Align cross-functional Guardant resources to support enterprise transformation
  • Drive cultural alignment and stakeholder engagement within complex systems
  • Advanced Contracting & Financial Strategy Leadership Lead sophisticated contracting strategies including: Risk-sharing agreements Multi-year enterprise contracts Value-based performance models
  • Shape internal commercial strategies based on payer-provider economics
  • Provide executive guidance on reimbursement and regulatory shifts
  • Data Analytics & Strategic Insight Leverage advanced population health analytics to inform national growth strategies
  • Interpret enterprise quality and utilization dashboards
  • Develop board-ready ROI analyses tied to quality improvement and cost avoidance
  • Identify national expansion opportunities through data-driven modeling
  • Organizational & Cultural Leadership Establish national enterprise playbooks adopted across regions
  • Mentor and develop Senior Managers and enterprise account leaders
  • Foster a culture of accountability, collaboration, and strategic excellence
  • Advise executive leadership on enterprise risk and growth opportunities
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