Bioinformatics Engineer — Spatial AI
LatchBio•San Francisco, CA
•$130,000 - $185,000•Hybrid
About The Position
At LatchBio, our AI agents help 4,000+ scientists analyze and interpret data from the next generation of spatial and multi-omic tools in biotech. We are seeking bioinformatics engineers with computational and experimental expertise in spatial biology to help pioneer a new category of agentic analysis tools.
Requirements
- Experience with end-to-end data analysis for one or more of the following spatial technologies: Seeker or Trekker (Slide-seq), MERFISH, DBiT-seq, Xenium, Visium, Stereo-seq, GeoMx, CosMx, or other similar assays
- Analyzed 3+ datasets from raw data to end insight for either publications or industry experiments with real world consequences
- Working understanding of kit specific quality control thresholds and intuition for numerical examples of positive or negative results (eg. 100K cells from 10X Chromium means something is wrong)
- Familiarity with the landscape of computational biology tools for spatial specific tasks (eg. cell segmentation, cell typing, ligand-receptor analysis)
Nice To Haves
- Published research that relied on modern spatial biology techniques.
- Engineered tools or packages in the spatial biology domain.
- Experience generating training data for AI agents or foundation models.
Responsibilities
- Own end-to-end spatial transcriptomics analyses across multiple projects: raw platform outputs → QC and failure diagnosis → cell segmentation and assignment → cell typing → DE/enrichment → spatial inference → defended biological claim.
- Build reproducible workflows and produce clear decision traces: what was filtered, why, what changed the conclusion, what would falsify the claim.
- Perform spatial reasoning beyond standard clustering: neighborhood and adjacency enrichment, spatial gradients and niches, spatial DE, and spatial autocorrelation-aware analyses.
- Debug platform and data issues with precision: turn messy results into crisp hypotheses, sanity checks, and a stepwise debugging plan.
Benefits
- $130k–$185k/yr (performance-based)
- Equity
- Unlimited PTO
- Waterfront office in China Basin
- Free lunch and dinner
- 100% premium covered on Blue Shield's platinum health plan ($0 premium, $0 deductible)
- 401(k) plan options
- Company-sponsored professional development
- Work visa sponsorship
- Team-wide science reading groups
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
No Education Listed
