Bioconjugation Scientist

Eurofins Scientific•Louisville, KY

51d•$80,000 - $100,000

About The Position

Position Summary: This role will support Antibody-drug conjugates (ADCs) linker and payload design, develop conjugation technologies, and downstream biochemical assays to enhance ADC biological and pharmacologic properties. We are looking for a strong scientist with good knowledge and hands-on experience in designing, preparing, and characterizing ADCs. This individual will be a self-motivated, responsible, and productive scientist who enjoys collaborating. They will be responsible for rigorous experimental design, data analysis, and data interpretation. This position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.

Requirements

A minimum of a master's degree in chemistry, biochemistry, or other related scientific discipline with a record of minimum 2 years in an industry lab-based independent research experience is required.
Deep expertise in using state-of-the-art conjugation methods and handling of potent linker-payloads.
Experienced in ADC characterization methods, including UV-Vis, SEC, HIC, RP, IEX, cIEF, and LC-MS.
Must be eligible to work in the United States indefinitely without restriction or sponsorship.

Nice To Haves

Experience with protein purification systems is preferred with hands-on experience and proficiency working with AKTA FPLCs.
Must be highly collaborative and able to effectively engage small-molecule research project teams to make rapid progress.
Demonstrated ability to work well with other accomplished professionals within and across functions/teams.
Ability to multi-task and shift priorities rapidly to meet tight deadlines.
Excellent written and verbal communicator.
Detail oriented and well organized.
Enthusiastic, self-motivated, and keen to improve processes.

Responsibilities

Prepare, purify, and characterize the high-quality antibody-conjugates (ADCs, ARCs, DACs etc.) with a high degree of independence in support of discovery and development of programs.
Implement state of the art bioconjugation technologies (cysteine, lysine, site-specific and other) and utilizing other bioorthogonal chemistries to generate bioconjugates.
Experienced in development of purification strategies (up to 100 mg) with affinity, ion-exchange, hydrophobic interaction, size exclusion, and tangential flow filtration.
Maintain thorough documentation of experimental procedures in electronic notebook or database, writing of reports and technical documents.
Engagement with multidisciplinary project teams to execute and interpret experiments.
Participate and present periodic updates and reports to management team.
Maintain a safe, pleasant, and efficient working environment.