Principal Scientist, Bioconjugation & Delivery

Alloy Therapeutics•Waltham, MA

1d•$126,000 - $144,000•Onsite

About The Position

Alloy Therapeutics is seeking a visionary and technical leader to serve as the subject matter expert for Bioconjugation and Delivery within our Genetic Medicines Unit. Whether you are a seasoned manager or an elite independent contributor, you will play a pivotal role in bridging the gap between innovative nucleic acid chemistry and transformative therapeutic delivery. You will be responsible for the end-to-end development, documentation, and implementation of process and analytical pipelines for Antibody Oligonucleotide Conjugates (AOCs) and targeted Lipid Nanoparticles (LNPs). This role requires a rare blend of deep technical mastery in conjugation chemistry and a strategic understanding of Quality by Design (QbD) to drive our internal programs and external partnerships forward.

Requirements

Education: PhD in Chemistry, Biochemistry, Chemical Engineering, or a closely related field.
Experience: Minimum of 10 years of post-academic experience, preferably within the biotechnology or pharmaceutical industry.
Minimum of 10 years of direct, hands-on experience with AOCs and state-of-the-art bioconjugation technologies.
Technical Mastery: Proven track record in developing conjugation chemistries for oligonucleotides (siRNA, ASO) and complex delivery vehicles (LNPs).
Expertise in analytical characterization (e.g. SEC-HPLC, IEX, IPRP, LC-MS).
Direct experience in process scale-up and tech transfer.
Soft Skills: Exceptional communication skills with the ability to translate complex data into actionable insights for diverse audiences, from internal scientists to partners.

Responsibilities

Process Leadership: Design and execute robust bioconjugation pipelines for AOCs (utilizing ASOs, siRNA) and targeted LNPs. This includes conjugating oligonucleotides, lipids, and nanoparticles to various targeting domains such as peptides, proteins, and aptamers.
Innovation: drive innovation to improve circulating half-life, tissue penetration, cellular uptake, and intracellular bioavailability of payloads
Method Development & Analytics: Establish high-resolution analytical methods and pipelines. You will be directly responsible for developing and proceduralizing in-process testing and finished product QC using HPLC (SEC, IEX, IPRP) and LC-MS.
QbD & Documentation: Operate withing Quality by Design (QbD) framework, maintaining meticulous records in our Electronic Lab Notebook (ELN). You will iterate between product descriptions and process knowledge to ensure scalable, high-quality manufacturing.
Supply Chain & Quality: Lead the review of raw materials and their quality attributes. Define process descriptions and manage technologies required for successful process scale-up.
Cross-Functional Collaboration: Act as a central pillar within Genetic Medicines and Alloy, collaborating seamlessly with the Nucleic Acid Chemistry and Biology groups will be essential. You will serve as a primary technical point of contact for external partners.
Thought Leadership: Represent Alloy Therapeutics at international conferences and in high-stakes partner presentations, showcasing our cutting-edge delivery capabilities.

Benefits

Competitive base and equity compensation commensurate with level of experience and independence
401(k) company match
Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
Company-paid disability (STD, LTD) and life insurance
Paid parental leave
Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)
Unlimited PTO (paid time off) and flexible schedules
Annual stipend for continuing education with commitment to your career through individualized professional development plan
Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness

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