Bioanalytical Scientist I/ Scientist II- 9-Month Contract Position
About The Position
About Hexagon Bio: Hexagon Bio is a drug discovery company focused on developing next-generation antibody–drug conjugates (ADCs) with novel payloads derived from natural products. We combine genomics, data science, machine learning, synthetic biology, automation, and medicinal chemistry to discover evolutionarily refined small molecules from microbial genomes and advance them toward transformative cancer therapies. Location: Menlo Park, CA Job description: Hexagon Bio is seeking a motivated and energetic Bioanalytical Scientist to join the Bioanalytical Chemistry team and play a key role in the in vitro and in vivo bioanalysis of ADC payloads and ADCs. This role is ideal for a hands-on, laboratory-focused researcher who thrives in a fast-paced environment and is eager to support our preclinical research pipeline.This is a 100% on-site lab-based role.
Requirements
- Degree in Analytical Chemistry, Chemistry, Pharmaceutical Sciences, or a related field.
- Post-degree (B.S./M.S./PhD) industry experience in biotech or pharma is preferred. Fresh PhD graduates are welcome.
- Demonstrated quantitative bioanalytical laboratory experience.
- Proven hands-on experience in LC-MS based quantitative bioanalysis.
- Strong fundamental understanding of mass spectrometry and LC applications.
- Hands-on experience with Triple Quadrupole (Sciex QQQ) MS instruments.
- Strong communication skills and highly collaborative cross-functionally across teams.
- Flexibility to adapt to shifting priorities and a genuine passion for lab-based scientific work.
Nice To Haves
- Knowledge and experience with LBA (Ligand Binding Assay) - ECL (Meso Scale Discovery) or ELISA based large molecule bioanalysis is a plus.
- Experience with ADCs and ADC payloads, or targeted oncology therapies is a strong plus.
Responsibilities
- Perform method optimization and implementation of LC-MS/MS (Liquid Chromatography- Mass Spectrometry) based small molecule and hybrid ADC bioanalytical and routine analytical assays.
- Execute quantitative LC-MS/MS assays in biological matrices for in vivo PK and TK studies.
- Develop sensitive MRM methods using best LC-MS/MS practices.
- Basic maintenance and troubleshooting of equipment- Triple Quadrupole (QQQ) and Single quad LC-MS
- Apply routine sample preparation using manual or automated liquid handling techniques (e.g., Hamilton Microstar).
- Maintain precise data records, analyze data sets, and interpret results.
- Collaborate closely with chemistry, protein science, and biology teams to ensure studies are designed and executed appropriately and data and conclusions are presented clearly
- Contribute to a team culture grounded in scientific rigor, transparency, and collaboration.
Benefits
- A dynamic, flexible environment with meaningful scientific ownership and impact.
- A transparent culture supported by regular All Hands meetings.
- Competitive compensation and a robust benefits package (medical, dental, vision, and voluntary benefits via TriNet).
- 401(k) plan
- Access to Menlo Park Labs amenities, including shuttle service, gym, climbing wall, pool, sports courts, café, bike storage, and EV charging.
- Team-building events such as Hexagon Happy Hours and company celebrations.
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What This Job Offers
Career Level
Entry Level
