Bioanalytical Scientist I/ Scientist II- 9-Month Contract Position

Hexagon Bio • Menlo Park, CA

16d • $120,000 - $160,000 • Onsite

About The Position

Hexagon Bio is seeking a motivated and energetic Bioanalytical Scientist to join the Bioanalytical Chemistry team and play a key role in the in vitro and in vivo bioanalysis of ADC payloads and ADCs.
This role is ideal for a hands-on, laboratory-focused researcher who thrives in a fast-paced environment and is eager to support our preclinical research pipeline.This is a 100% on-site lab-based role.

Requirements

• Degree in Analytical Chemistry, Chemistry, Pharmaceutical Sciences, or a related field. Post-degree (B.S./M.S./PhD) industry experience in biotech or pharma is preferred. Fresh PhD graduates are welcome.
• Demonstrated quantitative bioanalytical laboratory experience. Proven hands-on experience in LC-MS based quantitative bioanalysis.
• Strong fundamental understanding of mass spectrometry and LC applications. Hands-on experience with Triple Quadrupole (Sciex QQQ) MS instruments.
• Strong communication skills and highly collaborative cross-functionally across teams.
• Flexibility to adapt to shifting priorities and a genuine passion for lab-based scientific work.

Nice To Haves

• Knowledge and experience with LBA (Ligand Binding Assay) - ECL (Meso Scale Discovery) or ELISA based large molecule bioanalysis is a plus.
• Experience with ADCs and ADC payloads, or targeted oncology therapies is a strong plus.

Responsibilities

• Perform method optimization and implementation of LC-MS/MS (Liquid Chromatography- Mass Spectrometry) based small molecule and hybrid ADC bioanalytical and routine analytical assays.
• Execute quantitative LC-MS/MS assays in biological matrices for in vivo PK and TK studies.
• Develop sensitive MRM methods using best LC-MS/MS practices.
• Basic maintenance and troubleshooting of equipment- Triple Quadrupole (QQQ) and Single quad LC-MS
• Apply routine sample preparation using manual or automated liquid handling techniques (e.g., Hamilton Microstar).
• Maintain precise data records, analyze data sets, and interpret results.
• Collaborate closely with chemistry, protein science, and biology teams to ensure studies are designed and executed appropriately and data and conclusions are presented clearly
• Contribute to a team culture grounded in scientific rigor, transparency, and collaboration.

Benefits

• A dynamic, flexible environment with meaningful scientific ownership and impact.
• A transparent culture supported by regular All Hands meetings.
• Competitive compensation and a robust benefits package (medical, dental, vision, and voluntary benefits via TriNet).
• 401(k) plan
• Access to Menlo Park Labs amenities, including shuttle service, gym, climbing wall, pool, sports courts, café, bike storage, and EV charging.
• Team-building events such as Hexagon Happy Hours and company celebrations.

What This Job Offers

• Career Level: Entry Level