Associate Scientist
About The Position
Takeda Development Center Americas Inc. is seeking an Associate Scientist with the following duties: Lead from the lab to advance novel and differentiated products to the clinic by contributing to discovery projects focused on leveraging Vd1+ gamma delta T-cells as cancer treatment; Independently design, execute, and interpret well-defined functional in vitro, and ex vivo assays to understand the pharmacology and therapeutic mechanism-of-action of candidate molecules and play an active role in subsequent scientific discussions to drive decisions around Vd1 T-cells as a cancer therapy; Propose experiments based on internal results, external partners, and published reports and demonstrate leadership through effective communication of study plans and research results; Use immune cell characterization and functional assessments, such as high-parameter flow cytometry, multiplex cytokine measurement, co-culture cytotoxicity assessment, and other molecular- and cell-based assays and methodologies; Isolate, culture, and differentiate various immune cell populations from blood and tissue sources; Analyze, interpret, and present data to partners, and play an active role in the subsequent scientific discussions leading to important decisions and program-ensuring next steps; Participate in cross functional project team meetings to provide key scientific insight; Multi-task effectively and prioritize workload; Work collaboratively with internal cross-functional teams and acts as a Vd1 subject matter expert; Collaborate with other departments to meet deadlines and generate data crucial for the programs in execution; Contribute to the writing of relevant research reports to be included in regulatory filings; Prepare and present comprehensive technical or project reports and formal presentations and posters to full range of internal/external audiences; Maintain excellent laboratory notebook documentation and keep in compliance with Takeda policies. Up to 20% remote work allowed.
Requirements
- Master’s degree in Biology, Biosciences, or related field plus 18 months of related experience.
- Prior experience must include: Isolate, culture and expand Vd1 gamma delta T cells from blood, healthy tissue and tumor sources; Design and execute in vitro/ex vivo assays of Vd1 gamma delta T cell function, including cytotoxicity, survival, and proliferation; Analyze experimental data and determine the relevance of results based on background knowledge of Vd1 gamma delta T cell biology; Contribute to evaluation of novel immunotherapy products based on Vd1 gamma delta T cell biology; The design and optimization of RNA-FISH PrimeFlow Cytometric Assays for the identification of Vd1 gamma delta T cells.
Responsibilities
- Lead from the lab to advance novel and differentiated products to the clinic by contributing to discovery projects focused on leveraging Vd1+ gamma delta T-cells as cancer treatment
- Independently design, execute, and interpret well-defined functional in vitro, and ex vivo assays to understand the pharmacology and therapeutic mechanism-of-action of candidate molecules and play an active role in subsequent scientific discussions to drive decisions around Vd1 T-cells as a cancer therapy
- Propose experiments based on internal results, external partners, and published reports and demonstrate leadership through effective communication of study plans and research results
- Use immune cell characterization and functional assessments, such as high-parameter flow cytometry, multiplex cytokine measurement, co-culture cytotoxicity assessment, and other molecular- and cell-based assays and methodologies
- Isolate, culture, and differentiate various immune cell populations from blood and tissue sources
- Analyze, interpret, and present data to partners, and play an active role in the subsequent scientific discussions leading to important decisions and program-ensuring next steps
- Participate in cross functional project team meetings to provide key scientific insight
- Multi-task effectively and prioritize workload
- Work collaboratively with internal cross-functional teams and acts as a Vd1 subject matter expert
- Collaborate with other departments to meet deadlines and generate data crucial for the programs in execution
- Contribute to the writing of relevant research reports to be included in regulatory filings
- Prepare and present comprehensive technical or project reports and formal presentations and posters to full range of internal/external audiences
- Maintain excellent laboratory notebook documentation and keep in compliance with Takeda policies
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
