Sr. Associate Scientist/Associate Scientist

Legend Biotech US • Philadelphia, PA

10h • Hybrid

About The Position

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.
Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of immunotherapy in the treatment of multiple myeloma.
This role supports early-stage development of engineered Lentiviral vectors by developing and executing analytical methods and testing strategies that enable candidate evaluation and selection. The position will generate critical, decision-driving data across exploratory phases and partner closely with cross-functional stakeholders, including Quality, to ensure analytical readiness as programs advance toward impactful gene therapies at Legend Biotech.

Requirements

• BS degree with 3+ years relevant industry experience; MS degree with 1+ year or relevant industry experience; or PhD with +0 years of relevant industry experience in biochemistry, virology, molecular biology, cell&gene therapy, or a related field.
• Core technical foundation: Working knowledge of cell biology, biochemistry, and molecular biology concepts, including basic kinetic principles relevant to assay performance.
• Hands-on laboratory capability: Demonstrated ability to execute routine wet-lab experiments with attention to detail, consistency, and reproducibility.
• Data skills: Ability to analyze, interpret, and summarize experimental data: maintain accurate documentation and traceability.
• Communication: Clear written and verbal communication skills, including the ability to share results in reports, summaries, and presentations.
• Cross-functional mindset: Ability to work effectively with internal and cross-functional partners and respond to shifting priorities.
• Quality and compliance: Familiarity with good documentation practices and maintaining an organized lab environment to support data integrity and compliance expectations.
• Strong hands-on experience with LVV analytical assays, including cell transduction, flow cytometry-based functional titer, and genetic payload quantification (dPCR/qPCR).
• Experience with ligand-binding assays (e.g. ELISA, MSD) for protein quantification and/or residual impurity testing.
• Prior exposure to method development/optimization, qualification, and technology transfer in a developmental environment.
• Familiarity with data integrity expectations (traceability, controlled documentation) and partnering with QC teams.
• Ability to troubleshoot analytical methods using a data driven approach with appropriate escalation and documentation.
• Experience supporting lentiviral vector drug product characterization, including in vivo or translational studies.
• Comfortable working in a fast-paced environment, balancing short-term execution with longer-term assay/platform improvement.

Responsibilities

• Perform Lentiviral vector (LVV) functional titration through transduction and flow cytometry.
• Quantify LVV genetic payload concentration via dPCR.
• Determine LVV protein concentration determination via ligand binding assays (ie. ELISA, MSD).
• Support method development, qualification and technology transfer across internal teams.
• Prepare and deliver analytical technical reports, data summaries and presentations.
• Enable strong across cross-functional execution through clear communication and data delivery across internal and partner teams.
• Maintain an organized, compliant laboratory environment to ensure consistency, traceability, and data integrity.
• Troubleshooting routine assay using data-driven root-cause approach, document results, and coordinate corrective actions with senior staff as needed.

Benefits

• Benefits include medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one.
• We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays.
• Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance.
• We also provide commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level