Associate Scientist II, Neuroscience

PTC Therapeutics, Inc.•Livermore, CA

58d•Onsite

About The Position

PTC Therapeutics is a global commercial biopharmaceutical company. For over 25 years our team has been deeply committed to a unified purpose: Extending life’s moments for children and adults living with a rare disease. At PTC, we cultivate an inclusive culture where everyone feels valued, respected, and empowered. We welcome candidates from all backgrounds to join our team, fostering a strong sense of belonging. Visit our website to learn more about our company and culture! Site: www.ptcbio.com Job Description Summary: The Associate Scientist II, Neuroscience is responsible for conducting scientific experiments that contribute to research and drug discovery activities at PTC. This position assists in the conduct of early-stage research, the goal of which is the identification of New Chemical Entities (NCEs), as well as the advancement of research programs from the identification of screening hits to advanced lead optimization. The incumbent is also responsible for communicating experimental results to his/her supervisor and the project team. The Associate Scientist II, Neuroscience supports adherence to all regulatory requirements and company Standard Operating Procedures (SOPs) including as appropriate. . Job Description: ESSENTIAL FUNCTIONS Primary duties/responsibilities: Under general guidance, executes experiments, interprets, and communicates results as part of multi-disciplinary team(s). Applies relevant scientific principles and techniques to research problems. Maintains detailed laboratory notebooks. Maintains knowledge of state-of-the-art principles and techniques. Ability to independently troubleshoot experiments -designing controls, generating interpretable data. Presents findings internally and contributes to the publication of the work of the project team. Contributes to the development of patent applications as appropriate. Complies with all safety requirements. Contributes to laboratory needs, such as stockroom maintenance and ordering supplies. Involved in general lab duties as assigned. Specific duties may also include, but may not be limited to, the following: Assist in target deconvolution studies using a wide array of methodologies (including flow cytometry, ELISA, Western blot, RT-qPCR) Executes weekly cell-based screening assays to support hit to lead optimization efforts for early-stage discovery programs. Maintains multiple cell lines (thawing, passaging, seating) to support in vitro screening assays. Routinely uploads and reports data in a timely fashion which may also include communicating any delays or changes in workflow to a cross-disciplinary team. Provides support for the design and optimization of new assays, the goal of which is the identification of additional hits. Profiles selected compounds to better understand compound mechanism of action in additional cells and tissues.

Requirements

Experience with multi-color flow cytometry and immunophenotyping primary human cells.
Mammalian tissue culture experience with excellent sterile technique required.
Knowledge of basic Cell biology and Molecular biology
Exceptional attention to detail and time management skills
Strong analytical and problem-solving skills
Bachelor’s degree in a Biology scientific discipline, preferably Biology or Neuroscience or Immunology with a minimum of 6 years’ experience, OR, Master’s degree in a scientific discipline with a minimum of 2 years of relevant experience.
Demonstrates technical proficiency, and the ability to collaborate with others on cross functional teams in a fast-paced, matrixed, environment consisting of internal and external team members.
Possesses knowledge of scientific principles and concepts and keeps current with relevant scientific literature.
Proficiency with Microsoft Office- preferably MS Excel and MS PowerPoint.
Effective verbal and written communication and skills.
Analytical thinker with problem-solving skills and the ability to adapt to changing priorities and deadlines.
Effective planning, organization and time management skills including the ability to support and prioritize multiple projects.

Nice To Haves

Basic understanding of adaptive and innate immune system, especially as they relate to peripheral and nervous system inflammatory diseases.
Familiarity with establishing and routinely executing reproducible high-throughput assays
Proficiency with standard data analysis workflows, data visualization tools, and basic statistical analysis highly valued.
Knowledge of and ability to use standard molecular, cell biology, and immunology techniques.
Deep understanding in assay optimization and troubleshooting required.

Responsibilities

Under general guidance, executes experiments, interprets, and communicates results as part of multi-disciplinary team(s).
Applies relevant scientific principles and techniques to research problems.
Maintains detailed laboratory notebooks.
Maintains knowledge of state-of-the-art principles and techniques.
Ability to independently troubleshoot experiments -designing controls, generating interpretable data.
Presents findings internally and contributes to the publication of the work of the project team.
Contributes to the development of patent applications as appropriate.
Complies with all safety requirements.
Contributes to laboratory needs, such as stockroom maintenance and ordering supplies.
Involved in general lab duties as assigned.
Assist in target deconvolution studies using a wide array of methodologies (including flow cytometry, ELISA, Western blot, RT-qPCR)
Executes weekly cell-based screening assays to support hit to lead optimization efforts for early-stage discovery programs.
Maintains multiple cell lines (thawing, passaging, seating) to support in vitro screening assays.
Routinely uploads and reports data in a timely fashion which may also include communicating any delays or changes in workflow to a cross-disciplinary team.
Provides support for the design and optimization of new assays, the goal of which is the identification of additional hits.
Profiles selected compounds to better understand compound mechanism of action in additional cells and tissues.

Benefits

In addition to base salary, PTC employees are also eligible for short- and long-term incentives.
All eligible employees may also enroll in PTC’s medical, dental, vision, and retirement savings plans.

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