Scientist - Neuroscience & Immunology
About The Position
EMD Serono in Billerica, MA is seeking a Scientist to join the Discovery Biology group in Research Unit Neuroscience & Immunology (RU-N&I) team at our state-of-the-art research facility. The Scientist will contribute to the discovery of drugs for neurodegenerative/neuroinflammatory and autoimmune diseases. You will work collaboratively with an international team of scientists to develop novel therapeutics that align with the Neurology & Immunology portfolio. You will be responsible for the execution of in vitro cell-based assays that will further our mechanistic understanding of diseases and evaluate potential drug candidates.
Requirements
- Master’s degree in Biology, Neurobiology, Immunology or other Science discipline with 2+ years of laboratory experience in Academia, Pharma, Biotech or CRO
- OR
- PhD in Biology, Neurobiology, Immunology, or other Science discipline with 1+ years of laboratory experience in Academia, Pharma, Biotech or CRO
Nice To Haves
- Demonstrated experience with human iPSC-derived neural disease models
- Knowledge and hands-on experience in the following areas:
- Maintaining mammalian cell culture:
- Primary neurons or glia
- Co-culture and triculture systems
- PBMCs
- Transfection of cells to introduce siRNAs, ASO, or CRISPR-based gene editing tools to suppress or knockout specific genes
- Live-cell imaging and imaging analysis experience using an Incucyte or similar automated imager
- Immunocytochemistry and/or RNAscope
- Gene expression and protein analyses: DNA/RNA isolation, qPCR platforms (Applied biosystems QuantStudio, Nanostring, etc.), western blotting (SallySue, Wes)
- Bioanalytical assays: AlphaLISA, Meso Scale Discovery (MSD)
- Pharmaceutical industry/ Drug discovery experience
- Experience on a pipeline project team
- Proficient with research analytical software: GraphPad Prism, Microsoft Office, FIJI (or other image analysis software), QuantStudio
- Demonstrated ability to work independently in a self-motivated, pro-active manner
- Comfortable with designing and executing experiments based on protocols provided by literature, seminars, and/or other scientists
- Good understanding of basic drug discovery principles
- Enthusiasm, curiosity, and passion for exploring new biology with relevance to human disease
- Desire, demonstration of ownership, accountability, and ability to work efficiently in a fast-paced, high functioning cross-functional team
- Excellent interpersonal and written communication skills
Responsibilities
- Plan, execute, and lead in vitro studies using human iPSC-derived cell types, or cell lines to support target validation and drug candidate evaluation efforts
- Conduct translational biomarker discovery using patient samples or disease-relevant cell-based assays to support pharmacodynamics and target engagement biomarker discovery
- Operate a variety of laboratory equipment, including microscopes/automated imagers, flow cytometers, qPCR machines, and spectrophotometers
- Record data accurately in the Electronic Laboratory Notebook and maintain records per company policy and legal requirements
- Prepare data reports and presentations to lab heads, project teams, and at external meetings
- Independently design, execute, analyze, interpret, and troubleshoot experiments to support pipeline progression
- Provide technical support to colleagues in own area of expertise when necessary
- Work closely with members in RU-N&I to support departmental goals
Benefits
- health insurance
- paid time off (PTO)
- retirement contributions
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Number of Employees
5,001-10,000 employees
