Associate Director, Biostatistician

Madrigal Pharmaceuticals • Conshohocken, PA

20d • $183,000 - $224,000

About The Position

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. The Associate Director of Biostatistics is an experienced individual contributor that will independently lead biostatistical activities for assigned studies or projects at Madrigal Pharmaceuticals, covering all phases of clinical development and post-marketing efforts. This role will translate organizational objectives into statistical deliverables, drive the execution of statistical strategies, and ensure high-quality analytical outputs, serving as the statistical point of contact for study or project teams. The Associate Director will coordinate with other biostatisticians, programmers and cross-functional team members either within the company or at a CRO partner to ensure that Madrigal's analytical objectives are met. A working knowledge of clinical data structures (SDTM/ADaM), data management workflows, and statistical programming languages (SAS and/or R) is expected. This position reports into the VP of Biostatistics & Data Science.

Requirements

• Ph.D. in (Bio)statistics with 4-5 years, or a Master’s degree with 7+ years of experience in a Pharma or Biotech environment.
• Experience in design and analysis of clinical trials and healthcare datasets.
• Solid foundation in advanced statistical methods and computing (R, SAS).
• Effectively communicates complex statistical analyses and concepts to non-statisticians.
• Knowledge of regulatory guidelines in pharmaceutical development is required.
• Excellent organizational and communication skills.

Responsibilities

• This role will independently lead statistical modeling and analyses for assigned studies, in coordination with senior biostatisticians, programmers and cross-functional team members to meet R&D objectives.
• Perform and review complex statistical analyses, contribute to protocol development and prepare Statistical Analysis Plans as needed.
• Lead analysis efforts of clinical and real-world data to support evidence generation initiatives from randomized trials as well as observational studies.
• Establish effective collaborations with cross-functional team members, such as clinical research, medical affairs, clinical operations and data management.
• Contribute to scientific excellence via statistical innovation and participation in external conferences.

Benefits

• All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create.
• By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.
• Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans.
• We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings.
• In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family.
• The company also provides other benefits in accordance with applicable federal, state, and local laws.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree
• Number of Employees: 251-500 employees