Vice President, Supply Chain

4D Molecular Therapeutics•Emeryville, CA

5h•$308,000 - $354,000

About The Position

4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY The Vice President, Supply Chain is responsible for the end-to-end strategy, execution, and governance of global supply operations across all phases of development. This role ensures uninterrupted, compliant, and cost-effective supply of investigational and commercial products, comparators, ancillaries, and open-label therapies to support global clinical trials and commercial launch. This leader will build and scale a best-in-class supply organization, partner closely with Clinical Operations, CMC, Regulatory, Quality, and external vendors, and provide senior level oversight of supply risk, forecasting, and readiness in support of critical development and registration milestones.

Requirements

Bachelor’s degree in Life Sciences, Pharmacy, Engineering, or related field (advanced degree preferred)
18+ years of experience in clinical trial supply, CMC operations, or pharmaceutical supply chain
7+ years of senior leadership experience managing global teams and vendors
Demonstrated experience managing supply for global Phase 3 clinical trials
Prior experience leading supply strategy through regulatory submission and launch
Deep knowledge of clinical supply planning, comparator sourcing, and global distribution
Proven ability to operate effectively in high-complexity, fast-paced biotech environments
Executive presence and strategic thinking
Strong cross-functional influence without direct authority
Exceptional problem-solving and risk-mitigation skills
Data-driven decision making and forecasting expertise
Ability to balance speed, quality, and compliance
Clear, confident communicator with internal and external stakeholders

Nice To Haves

Experience supporting biologic, gene therapy, or specialty ophthalmology products
Strong background in managing constrained or high-risk supply scenarios
MBA or advanced scientific degree a plus

Responsibilities

Define and execute the global supply strategy across early- and late-stage programs, including Phase 1–3, commercial launch, and post-approval commitments
Serve as the enterprise leader for clinical trial supply governance, risk management, and scenario planning
Provide senior-level input into development timelines, enrollment strategies, and global expansion plans based on supply feasibility
Anticipate and proactively mitigate supply risks (manufacturing capacity, comparator shortages, import/export constraints, depot limitations, based on deep experience with global supply chain)
Drive BLA-enabling supply chain activities, including shipping validation, planning for commercial labeling processes, and temperature monitoring strategies. Provide support for combination device strategy (such as co-packaging with needles and syringes, pre-filled syringes, and other approaches, including device compatibility strategies), and launch forecasting and planning.
Oversee end-to-end clinical supply execution, including: Demand forecasting and supply planning Packaging, labeling, and distribution Depot strategy and inventory management Open-label and rescue medication sourcing (e.g., comparator biologics) Management of drug product inventory, including production needs, regulatory timing, and QP approval for introduction of new lots
Balance supply needs with financial ones, including management of cost, expiration dating, potential delays, and clinical enrollment projections.
Ensure timely and compliant supply to global investigational sites while supporting enrollment acceleration and protocol amendments
Lead contingency planning for constrained supply scenarios and high-enrolling sites
Select, manage, and govern global supply vendors (CMOs, depots, couriers, comparator sourcing partners), and work closely with global CROs (pack and label vendors, clinical trial vendors) to ensure smooth uptake in new countries
Establish performance metrics, KPIs, and escalation pathways to ensure vendor accountability
Negotiate contracts and manage budgets for clinical supply operations
Drive continuous improvement and cost optimization across the supply network
Partner closely with: Clinical Operations (site activation, enrollment strategy) CMC / Technical Operations (manufacturing timelines, release) Quality Assurance (GxP compliance, audits, inspections) Regulatory Affairs (import/export, labeling, country requirements) Commercial team (BLA and launch planning, commercial supply)
Act as a strategic advisor to program teams and executive leadership on supply-related decision-making
Ensure full compliance with GMP, GDP, ICH, FDA, EMA, and global regulatory requirements
Maintain inspection-ready systems, documentation, and processes
Lead responses to regulatory inspections, audits, and findings related to supply chain
Build, mentor, and lead a high-performing global supply chain organization
Establish scalable processes, SOPs, and operating models appropriate for company growth, including selection and introduction of appropriate software tools
Foster a culture of accountability, transparency, and proactive problem-solving
Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time