Vice President, Programs and Portfolio Office(PPO)
About The Position
Definium Therapeutics, formerly known as Mind Medicine, is a clinical stage biopharmaceutical company developing novel product candidates to treat brain health disorders. Our mission is to be the global leader in the development and delivery of treatments that unlock new opportunities to improve patient outcomes. We are developing a pipeline of innovative product candidates, with and without acute perceptual effects, targeting neurotransmitter pathways that play key roles in brain health. Founded in 2019, we are continuously expanding our presence and global footprint. We are constantly searching for high-impact individuals in various clinical, technical and business operations domains to strengthen our team of patient-centric, intelligent individuals. The Vice President, Programs and Portfolio Office (PPO) will play a critical leadership role in driving strategic alignment, operational excellence, and execution discipline across Definium’s portfolio of clinical and research programs. This individual will oversee the integrated program management function and ensure that portfolio decisions are data-driven, risk-aware, and aligned with corporate goals. As a member of the R&D leadership team, the VP, PPO will partner closely with the CEO, CMO, CFO, asset strategy leads, and functional heads to set priorities, track and anticipate resource allocation, and guide teams toward successful outcomes across all stages of development.
Requirements
- Advanced degree in life sciences, medicine, or related field (Ph.D., Pharm.D., or M.S.) strongly preferred
- 15+ years of experience in biotechnology or pharmaceutical program and portfolio management, including leadership of late-stage clinical programs
- Proven track record in leading cross-functional development teams and managing complex program portfolios
- Deep understanding of the drug development process, from IND through NDA and commercialization
- Exceptional strategic thinking, analytical, and communication skills
- Ability to thrive in a dynamic, fast-growing environment where hands-on leadership is required
Responsibilities
- Lead portfolio planning and prioritization to align R&D investments with corporate strategy and value creation
- Oversee governance processes, including portfolio reviews and decision-making forums
- Develop frameworks for scenario planning, risk management, and budget optimization
- Build and lead a high-performing program management team responsible for the planning, coordination, and execution of all development programs (preclinical through late-stage)
- Ensure cross-functional alignment, transparency, and accountability across clinical, regulatory, CMC, and commercial readiness functions
- Oversee integrated project plans, timelines, milestones, and budgets
- Interface with key external partners to integrate external project management with our internal cross-functional teams
- Establish best practices, tools, and templates for program governance, reporting, and performance tracking
- Serve as a key interface between scientific/clinical teams and executive leadership to ensure timely, informed decision-making
- Drive continuous improvement and a culture of collaboration, agility, and excellence
- Provide regular program and portfolio updates to executive leadership and the Board of Directors
- Partner with Finance and Strategy functions on long-range planning and external communications
Benefits
- 100% paid health benefits including Medical, Dental and Vision for you and your dependents
- 401(k) program with company match and vesting after the turn of the first month after your start date
- Flexible time off
- Generous parental leave and some fun fringe perks!
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What This Job Offers
Job Type
Full-time
Career Level
Executive
Education Level
Ph.D. or professional degree
