Vice President, Clinical Business Operations and Strategy

Revolution Medicines•Redwood City, CA

5d•Hybrid

About The Position

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: The Vice President, Clinical Business Strategy and Operations serves as a critical strategic partner to the SVP of Clinical Operations and the Development Leadership Team, driving alignment, execution, and operational excellence related to the business operations of our global clinical programs. This role integrates visionary leadership, high-level strategic planning, organizational enablement, fiscal strategy and governance oversight with leadership of the company’s global clinical business operations activities—ensuring that partnerships, vendors, and financial commitments align with scientific and corporate priorities. The ideal candidate is a seasoned biotech executive who thrives at the intersection of science, strategy, and business operations, with demonstrated expertise in clinical outsourcing, vendor management, cross-functional execution, strategic planning, clinical finance, project management, business planning & operations, leadership and mentoring, and fostering cross organizational collaboration within high-growth scaling biotechnology organizations. In this role, you will be responsible for the strategic planning, operational design and structure of, and accountable for the implementation and continuation of, procedures, governance and expansions of processes and procedure to enable Revolution Medicines clinical trials and operations. Specifically, responsibilities include: Create long-term strategic direction for Revolution Medicines’ clinical business operations, ensuring that outsourcing models, vendor partnerships, and financial strategies support the company’s integrated R&D and commercialization goals. Shape the enterprise approach to global clinical vendor strategy and operational scalability. Serve as trusted advisor and thought partner to the SVP, Clinical Operations, the EVP, Development and the Chief Development Office as well as Development Leadership Team to translate the evolving strategic vision of clinical operations and policies into operational execution. Create functional alignment with Finance, Legal and Development functions and leadership for financial and resource deployment with strategic priorities to support timely clinical study execution through budgeting, forecasting, and strategic vendor utilization as well as contract risk and audit readiness. Lead transformation of outsourcing and business partnership models to drive efficiency of our clinical trial execution in alignment with our corporate objectives and growth trajectory, expanding to business operations in other Development functions as appropriate Lead the global vendor outsourcing function, responsible for developing, negotiating, and managing agreements with CRO’s clinical vendors, investigators, clinical sites, and strategic partners within clinical operations and development as a whole. Establish standardized contracting frameworks, performance metrics, and SLAs to enhance consistency, speed, and compliance across programs. Design and operationalize a scalable operating model that can deliver required CTA volumes based on RevMed needs by optimizing processes and reducing complexity. Identify gaps, align building of solutions and drive the evaluation, selection, deployment, and oversight of clinical outsourcing agreements processes and practices. Develop and maintain a vendor governance model that ensures transparency, quality, and fiscal responsibility across global partnerships. Establish metrics and governance to ensure performance, compliance, and fiscal responsibility. Implement metrics and dashboards to monitor contracting cycle times, vendor performance, and clinical business operations efficiency. Establish functional effectiveness by cultivating leadership capability across the CORE team, broader Clinical Operations & Development functions and embedding a values-driven culture of collaboration, innovation, accountability, growth and strategic foresight. Partner with Development Program Management, Business Operations, and other functional leaders (Quality, Regulatory, Finance, Legal) to develop and implement cross-functional processes that maximize organizational impact, scalability, and compliance with ICH/GCP and global standards. Set roadmap for strategic change management across clinical operations (and as required across development organization), leveraging best practices to ensure successful and sustainable change adoption and continued scalability of business operations in alignment with organization wide strategies and goals.

Requirements

20+ years of progressive leadership experience in biotechnology or pharmaceuticals, including at least 8 years in clinical outsourcing, contracting, or business operations, preferably with Oncology experience.
Minimum of 10 years clinical operations systems project and line management experience.
Master’s degree in business, finance, or life sciences required; MBA preferred.
Extensive experience managing business operations related to global phase 1-3 clinical trials budgets and translating the experiences into operational systems.
Demonstratable record of strong leadership and teamwork.
Strong understanding of clinical contracting, budgeting and development processes, outsourcing models, and global regulatory frameworks.
Demonstrated excellence in vendor negotiation, contracting, and governance across CRO, lab, and site partnerships.
Must have a working knowledge of interplay/interactions related functions related to clinical trial conduct.
Exceptional organizational, analytical, and interpersonal skills with the ability to influence and drive results across functions.
Strong working knowledge of FDA Regulations, ICH Guidelines and GCPs governing the conduct of clinical trials.
Thrives in a collaborative team setting and is driven by a desire to deploy innovative approaches and technologies in a high-energy environment.
Excellent written and verbal communication skills.
Ability to act as an excellent ambassador for Revolution Medicines in interactions with key opinion leaders, scientific advisors, corporate partners and, where necessary, investors.
Demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute goals as a member of an interdisciplinary team is extremely important.
Strategic and Systems Thinking.
Financial and Contractual Acumen.
Executive Presence and Communication.
Operational Rigor and Process Excellence.
Change Leadership and Organizational Design.
Collaborative and Servant Leadership Style.

Nice To Haves

Experience in working with cooperative group studies and investigator sponsored trials.
Experience operating in fast-paced, early to mid stage biotech environments.

Responsibilities

Create long-term strategic direction for Revolution Medicines’ clinical business operations, ensuring that outsourcing models, vendor partnerships, and financial strategies support the company’s integrated R&D and commercialization goals. Shape the enterprise approach to global clinical vendor strategy and operational scalability.
Serve as trusted advisor and thought partner to the SVP, Clinical Operations, the EVP, Development and the Chief Development Office as well as Development Leadership Team to translate the evolving strategic vision of clinical operations and policies into operational execution.
Create functional alignment with Finance, Legal and Development functions and leadership for financial and resource deployment with strategic priorities to support timely clinical study execution through budgeting, forecasting, and strategic vendor utilization as well as contract risk and audit readiness.
Lead transformation of outsourcing and business partnership models to drive efficiency of our clinical trial execution in alignment with our corporate objectives and growth trajectory, expanding to business operations in other Development functions as appropriate
Lead the global vendor outsourcing function, responsible for developing, negotiating, and managing agreements with CRO’s clinical vendors, investigators, clinical sites, and strategic partners within clinical operations and development as a whole.
Establish standardized contracting frameworks, performance metrics, and SLAs to enhance consistency, speed, and compliance across programs.
Design and operationalize a scalable operating model that can deliver required CTA volumes based on RevMed needs by optimizing processes and reducing complexity.
Identify gaps, align building of solutions and drive the evaluation, selection, deployment, and oversight of clinical outsourcing agreements processes and practices.
Develop and maintain a vendor governance model that ensures transparency, quality, and fiscal responsibility across global partnerships.
Establish metrics and governance to ensure performance, compliance, and fiscal responsibility.
Implement metrics and dashboards to monitor contracting cycle times, vendor performance, and clinical business operations efficiency.
Establish functional effectiveness by cultivating leadership capability across the CORE team, broader Clinical Operations & Development functions and embedding a values-driven culture of collaboration, innovation, accountability, growth and strategic foresight.
Partner with Development Program Management, Business Operations, and other functional leaders (Quality, Regulatory, Finance, Legal) to develop and implement cross-functional processes that maximize organizational impact, scalability, and compliance with ICH/GCP and global standards.
Set roadmap for strategic change management across clinical operations (and as required across development organization), leveraging best practices to ensure successful and sustainable change adoption and continued scalability of business operations in alignment with organization wide strategies and goals.