Vertex Spring 2026 Co-op, Technical Operations, Process Analytical Technology (PAT)

Vertex Pharmaceuticals•Boston, MA

9d•$20 - $50•Hybrid

About The Position

The Vertex Technical Operations - Process Analytical Technology Co-Op program is a 6-month experiential training program for students currently working towards an undergraduate or advanced degree in Chemistry, Analytical Chemistry, Science, Math, Statistics, Engineering, or other related fields. If you are passionate, collaborative, and growth-minded, a co-op at Vertex will help you gain meaningful experience in our technical operations functional areas and serve as a launchpad for your career. Please note that Vertex reviews applications on a rolling basis and reserves the right to close this job posting prior to the listed deadline. Technical Operations – Process Analytical Technology (PAT) is part of Pharmaceutical Operations and responsible for process analytical control of Vertex commercial continuous manufacturing processes. This internship allows the candidate to work with a highly diverse group of scientists (i.e Technical Operations- Process and Automation) to solve complex problems encountered in the continuous commercial production/manufacturing of drug products. This intern will have the unique opportunity to explore new horizons to PAT which utilizes material sparing techniques for calibration building – laboratory simulations of manufacturing conditions and universal sample preparations approaches. This will involve building advanced multivariate models from acquired spectroscopic data of drug product intermediates.

Requirements

Enrolled in an undergraduate or graduate program in Analytical Chemistry, Chemistry, Science, Math, Statistics, Engineering , or another related field.
Basic computer and MS Office Skills
Knowledge in fundamentals of vibrational spectroscopies (IR, Raman, NIR)
Demonstrated proficiency in intricate data manipulation using Microsoft Excel
Comfort in handling and organizing large data sets
Legal authorization to work in the United States, now and in the future.
You must be enrolled in an advanced degree program if graduating before June 2026
You must be available to work full-time, 40 hours per week from January – June 2026

Nice To Haves

Knowledge about analytical chemistry, especially applied to small molecule pharmaceuticals
Knowledge in oral solid dosage pharmaceuticals manufacturing processes and formulations
Experience with multivariate data analysis and model building (PCA, PLS, SIMCA)
Experience with software tools such as Unscrambler or PLS toolbox
Experience with coding in MATLAB
Motivated team player and enthusiastic to learn new skills

Responsibilities

Design and execute activities and experiments to formulate calibration blends using material sparing techniques and measure them spectroscopically.
Become proficient in statistical modeling of spectroscopic data.
Develop multivariate predictive models (PCA, PLS, etc.) to assess the potency of drug product intermediates.
Develop new and evaluate existing methods for generating simulated calibration spectra and evaluate their accuracy
Support the progress of automated off-line chemometric model assessments.
Report and present results of work to key stakeholders and leadership